Palliative care 2017

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Liver SBRT- modeling of response

• TCP modeling for alfa/beta of 10Gy

(BED max)

• 90% TCP at 2 y needs BED 209 Gy

10

for

patients

never treated with chemo

and

inreases to 286 Gy

10

after chemo.

• Larger PTV(>70.4 cc) and

simple motion

managemnet

predicted signifantly lower

TCP

• Favourable histology

: breast cancer: 157

Gy

10

with prior chemo or 80 Gy

10

without

chemo

• SBRT for liver metastases yields a

strong dose–response relationship that is

modified by factors such as

chemotherapy and metastases

histology.

(Klement RJ, R&O 2017)

Klement RJ, R&O 2017

JK 36/49