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A Practical Example: SBRT Lung Case
 T1 primary lung lesion: 3 x 18 Gy @ 80% N = 3, β = 0.84
 Alignment on time-averaged tumor position by CBCT
 SD of the penumbra is 6.4 mm σpen = 6.4 mm
 E2E test device error (Σ) = 0.4 mm Σ1 = 0.4 mm
 Localization (delineation) error = 2.0 mm (1 SD) Σ2 = 2.0 mm
 Systematic error = 1.0 mm (1 SD) Σ eff = 1.0 mm
 Random error = 1.0 mm (1 SD) σeff = 1.0 mm
 Intra-fraction amplitude = 1 – 25 mm σr = 0.4 – 9.0 mm