949 / 1224
/
SBRT for re-irradiation
16
Spinal cord tolerance – reirradiation:
Animal studies
56 Rhesus monkeys, SFD 2.2Gy to 44Gy
Reirradiation
• 57.2Gy after 1 and 2 years
• 66Gy after 2 and 3 years
4 / 45 animals developed RMP
Optimistic model:
Recovery of 76%, 85% and 101%
after 1, 2 and 3 years
Conservative model:
Recovery of 61%
Ang IJROBP 2001
„Optimistic“ model
„Pessimistic“ model