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Physiological correlates
Amplitude
Relative blood volume
Interstitial space
k
ep
Perf > Diff
Diff > Perf
Diffusion
Perfusion
Diffusion = Transcapillary exchange
Depends on:
Permeability, capillary exchange surface
Normal spine
T1w post contrast FS Parameter image
Time-intensity curve
Diffuse infiltration by multiple myeloma
Amplitude vs. infiltration degree
Low infiltration
degree
High infiltration
degree
0.0
0.1
0.2
0.3
0.4
0.5
0.6
n = 11
n = 5
p<0.01
Nosas-Garcia et al., 2005
Amplitude vs. vessel density
Lowvesseldensity Highvesseldensity
0.0
0.1
0.2
0.3
0.4
0.5
0.6
Normalized amplitude
n = 18
n = 6
p<0.01
Nosas-Garcia et al., 2005
Prognostic information of DCE-MRI
Hillengass et al., Clin Cancer Res 2007
Months since first dMRI
n=65