463 / 1726
Conventional Arm
IMRT Arm
Pts randomized
100
100
Compliance to Rx
95
97
Acute toxicities
Acute GI
Gr II
Gr III
15
03
12
02
Acute GU
Gr II/ Gr III
06
05
Acute hematological
Thrombocytopenia (Gr II/III)
Neutropenia (Gr II/III)
Anemia Gr I
Anemia Gr II/ III
05
08
16
04
03
03
22
04
Late Toxicities
RT Proctitis
Gr II
Gr III / IV
02
03
09
08
RT Cystitis
Gr II
Gr III
03
01
06
03
Interim analysis, comparable toxicities
Shrivastava
ICARO& ASTRO
2013
•
Interim analysis
•
Higher rate of acute toxicity
with IMRT
•
Final analysis expected