464 / 1726
PARCER trial (TMH), focus on bowel doses and morbidity
Bowel Dose
IMRT
3DCRT
P value
V15 Small Bowel
≥ 275 cc
8 (13.1%)
25 (44.6%)
<0.0001
V40 Small Bowel
≥ 150 cc
1 (1.6%)
26 (46.4%)
<0.0001
V15 Peritoneal Cavity
≥ 1200 cc
15 (24.5%)
24 (42.8%)
0.06
V40 Peritoneal Cavity
≥ 750 cc
1 (1.6%)
20 (35.7%)
<0.0001
Phase III RCT of
Postoperative
Adjuvant Conventional Radiation (3DCRT)
Vs. Image Guided Intensity Modulated Radiotherapy (IG-IMRT) for
Reducing Late Bowel Toxicity in Cervical Interim Analysis
•
Interim analysis
•
Significant less volume irradiated with IMRT after surgery
Chopra
ASTRO, 2015