465 / 1726
PARCER, primary endpoint late bowel morbidity
•
Median Follow Up = 20 months
•
14% absolute difference in late Grade ≥ 3toxicity
•
Statistically insignificant at interim analysis
IG-IMRT
3DCRT
p value
Late Grade ≥ II toxicity
(Primary Endpoint)
11.4%
25%
0.13
Late Grade ≥ III toxicity
(Exploratory Endpoint)
3.2%
17.8%
0.02
Chopra
ASTRO, 2015