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PDE5-005
they are linear from 50 to 1000 ppm in the sample. The
consumables are inexpensive. The cost of the DART
itself, compared with other DART instruments on the
market, is reasonable. It would still need a highly skilled
operator for the instrument.
Method Clarity
The method is very clear and easy to follow. All the
parameters necessary for operation of the mass
spectrometer are included in the method and easy to
use.
Pros/Strengths
small sample size, easy extraction, ease of automation,
use of MS/MS for selectivity and sensitivity, very low
LOD, ability to do triggered MRM's.
Cons/Weaknesses
Needs the use of a highly skilled operator.
Supporting Data
General Comments
The data is easy and straight forward. The experimental
conditions are outlined and straight forward. It uses
internal standards to help with the Quantitation. The
method is very specific and very selective.
Method Optimization
The optimization is very clear and straight forward. It has
been optimized for the compounds of interest molecular
mass.
Performance Characteristics
Analytical Range:
50 - 1000 ppm in the sample, meets requirements of
SMPR 2014.011
LOQ:
50 mg/kg meets 2014.011
Accuracy/Recovery
Average of 83.2 for all 15 compounds. Meets SMPR
requirements of 2014.011
Precision (RSDr)
Overall, precision meets SMPR 2014.011
Reproducibility (RSDR)
Overall, reproducibility meets SMPR 2014.011
System Suitability
Safety Review
Is the method safe to use as written?
Yes
Are there any safety concerns with
any component, instrument, reagent
or instruction of the method? If yes,
please clearly state the concerns.
Yes, safety statement is there in the method.