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CHON-002

Question

Response

General

AOAC Method Number:

CHON-002

Method Title:

Isotachophoretic Determination of GA and CS in Dietary

Supplements

Method Author(s):

Vaclavikova, E., et al.

Reviewer Name:

Curtis Phinney

Summary of Method

This method is based on (cITP), a capillary electrophoretic

technique based on ionic mobility, with conductivity and UV

(254 nM) detection.

Method Scope / Applicability:

Applicable to dietary supplements and raw materials.

General Comments About the

Method:

The technique is very well described in two related papers.

The authors investigated the role of economically significant

and common impurities in great detail.

Method Clarity

The method is described fully, with considerable background

and supporting information.

Pros/Strengths

Rigorous experimental design

Addresses significant quality concerns

Addresses economic adulterants

Simple sample prep and reagents

Cons/Weaknesses

Validated using alternate guidelines (ICH '95, '96)

No explicit system suitability step

No inter lab data, 2-day inter day study

Supporting Data

General Comments

Extensive supporting data and discussion of interferences.

Supporting data may not address all SMPR

Method Optimization

Exhaustively optimized method. Raw data is not presented

in this paper.

Performance Characteristics

Analytical Range:

< 1% to 100%