The State of Biophysics - Biophysical Journal
|
Intro |
2 |
|
Introduction to Biophysics Week: What is Biophysics? |
2 |
|
References |
4 |
|
01 |
5 |
|
Cellular Biophysics |
5 |
|
Microscopy: a major theme in cellular biophysics |
5 |
|
Looking ahead |
6 |
|
Acknowledgments |
7 |
|
References |
8 |
|
02 |
9 |
|
Optogenetics: Turning the Microscope on Its Head |
9 |
|
The fluorescent protein palette |
16 |
|
Blinking, highlighting, and binding |
9 |
|
Blinking |
9 |
|
Highlighting |
10 |
|
Binding |
10 |
|
Microbial rhodopsins bring light to the membrane |
11 |
|
Converting microbial rhodopsins into reporters |
12 |
|
Optogenetic control inside the cell |
13 |
|
The microscope as a two-way tool |
13 |
|
Future opportunities |
14 |
|
Conclusions |
14 |
|
References |
14 |
|
03 |
16 |
|
Probing Nature’s Nanomachines One Molecule at a Time |
16 |
|
Proteins as nanomachines |
16 |
|
Single-molecule measurement technologies |
16 |
|
Single-molecule localization and tracking stoichiometry |
17 |
|
Single-molecule FRET: conformational changes and molecular interactions |
17 |
|
Marriage of single-molecule FRET and optical tweezers |
18 |
|
Future outlook |
18 |
|
References |
19 |
|
04 |
20 |
|
The Current Revolution in Cryo-EM |
35 |
|
The “hardware” |
20 |
|
The “software” |
29 |
|
Conclusions |
23 |
|
References |
23 |
|
05 |
25 |
|
Making Sense of Intrinsically Disordered Proteins |
16 |
|
Acknowledgments |
28 |
|
References |
28 |
|
06 |
29 |
|
Inherited Arrhythmias: Of Channels, Currents, and Swimming |
29 |
|
Clinical case: the unexpected end of a swimming trip |
29 |
|
Inherited arrhythmias and sudden cardiac death |
29 |
|
Ion channels and cellular electrical activity |
29 |
|
Electricity and cellular orchestration |
30 |
|
LQTS: how delay causes acceleration |
31 |
|
Stress as trigger for TdP tachycardia |
32 |
|
The role of biophysical evidence in drug herapy development for inherited arrhythmias |
33 |
|
The role of biophysics in other channelopathies |
33 |
|
Advice for the young swimmer: staying on the safe side (of the pool) |
34 |
|
References |
34 |
|
07 |
35 |
|
Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems |
35 |
|
The cardiac electrical system |
36 |
|
The cardiac mechanical system |
37 |
|
Hemodynamics, oxygen delivery, and metabolism |
38 |
|
Future prospects |
38 |
|
Acknowledgments |
39 |
|
08 |
40 |
|
How Viruses Invade Cells |
40 |
|
Acknowledgments |
44 |
|
References |
14 |