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ESTRO

Combined chemo- and radiotherapy treatment:

Cellular / molecular interaction

DNA damage

Chromosome

Cell

Apoptosis

induction repair

aberration

Cycle

5-Fu

MTX

HU

dFdC

F-ara-A

-

?

?

-

-

-/+

?

-/+

-

-

-

?

+

+

+

+

?

+

+

+

?

?

?

-

-?

Antimetabolites