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ESTRO

DNA damage

Chromosome Cell

Apoptosis

induction repair

aberration

Cycle

Etoposide

Camptothecine

Adriamycine

-

?

?

±

+?

?

±

-

-

+

+

-/+

?

+

-/+

Topo-isomerase inhibitor

Combined chemo- and radiotherapy treatment:

Cellular / molecular interaction