ESTRO
DNA damage
Chromosome Cell
Apoptosis
induction repair
aberration
Cycle
Etoposide
Camptothecine
Adriamycine
-
?
?
±
+?
?
±
-
-
+
+
-/+
?
+
-/+
Topo-isomerase inhibitor
Combined chemo- and radiotherapy treatment:
Cellular / molecular interaction