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ESTRO

DNA damage

Chromosome Cell

Apoptosis

induction repair

aberration

Cycle

Mitomycin-C

Bleomycin

Actinomycin-D

?

?

?

?

-

+?

-

-/+

?

?

+

?

?

?

-

Antibiotics

Combined chemo- and radiotherapy treatment:

Cellular / molecular interaction