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9
Experimental studies
Late effects
17
Skin
•
Late radiation effects – mouse hind-limb
18
Two 10-fraction
courses separated by
6 months
Effect of re-irradiation
more pronounced
after more aggressive
initial treatment
Poorer retreatment
tolerance than for
early skin reactions
Brown & Probert Radiol 1975
Reirradiation dose per fraction (Gy)
3
4
5
6
7
Severity (arbitrary units)
0
1
2
3
4
5
6
7
hind limb deformation
treatment
alone
post 10 × 5 Gy
post 10 × 4 Gy