806 / 1173
1/03/2016
15
Head & neck
29
Salama Int J Radiat Oncol Biol Phys 2006
115 patients
reirradiation + various CT
Initial treatment median 68 Gy
Retreatment median 65 Gy
Head & neck
•
Head & neck reirradiation:
selection criteria
•
Patient
related considerations
•
No severe sequelae of previous radiation treatment
•
No significant comorbidities
•
PET-CT is suggested for staging
•
Interval between RT courses: at least 6 months, preferably longer (1y)
•
Better prognosis:
•
Previous surgery
•
Small (<30cm³) tumor size; caution with bulky tumors (>60cm³)
•
True second primary tumors (as compared to recurrences)
•
Tumors in nasopharynx and larynx
•
EGFR expression/HPV status: uncertain (needs to be evaluated in the
context of re-irradiation)
30
Cacicedo Cancer Treatment Reviews 2014