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Pitfalls
•
Problems with clinical data!
•
Extremely heterogeneous populations
•
Curative and palliative intent in the same series
•
Changes in staging and radiotherapy techniques
•
Changes in normal tissue scoring
Experimental animal systems
have been
essential to
understand the radiobiology of retreatment tolerance
25
Head & neck
•
Review post-op RT for
recurrent HNSCC
•
Major late
complications are
fibrosis, mucosal
ulceration/necrosis and
osteoradionecrosis
•
Nevertheless,
high-
dose re-irradiation
recommended
26
Kasperts Oral Oncol 2005