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Rectum
•
Palliative reirradiation for
recurrent rectal cancer (n=52)
•
Median reirradiation dose 30.6 Gy,
•
2 × 1.2 Gy/f per day or 2 Gy/f per
day
•
Significantly
lower risk of late
complications with
hyperfractionated treatment
delivery (2 × 1.2 Gy/day)
33
Lingareddy V et al. Int J Radiat Oncol Biol Phys 1997;38:785–90
Rectum
•
Pre-op retreatment
(hyperfractionation +
chemotherapy) for
rectal cancer
•
Initial dose ≤55Gy;
Re-irradiation dose
30Gy + boost of
10.8Gy with 2x1.2Gy
per day
•
Low acute toxicity
and acceptable
incidence of late
complications
34
Valentini Int J Radiat Oncol Biol Phys 2006