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Summary clinical data
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Re-irradiation is an option for patients with recurrent
or second tumors
•
Risk of normal tissue damage and impact on quality
of life must be taken into account
Take home messages
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If tolerance has already been exceeded: no re-
irradiation possible without loss of function
•
Early effects
•
Low to moderate doses:
•
Restitution of original tolerance may be complete after tissue-
specific and dose-dependent time intervals
•
High doses:
•
Residual damage may remain for longer intervals, particular at the
stem cell level, which is not necessarily reflected in functional tissue
compartments
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