812 / 1173
1/03/2016
21
Take home messages
•
Late-responding tissues
•
Partial (CNS, lung) or complete (skin) restoration of
tolerance after low to moderate doses (<60% initial
tolerance)
•
Progression of damage at subclinical level (kidney,
urinary bladder) must be expected thus precluding re-
irradiation without exceeding tolerance
41
Take home messages
•
Strategies for retreatment
•
Alternative treatment options must be considered before
re-irradiation
•
If (curative) re-irradiation is to be considered
•
Use best available treatment planning
•
Consider hyperfractionation for treatment with curative intent
•
Consider combined EBRT and brachytherapy
42