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Urinary bladder
•
Retreatment tolerance mouse bladder
21
total dose (Gy)
0
5
10 15 20 25 30 35
micturition frequency
0
5
10
15
20
2F / 1 d
2F / 3 mo
2F / 9 mo
Stewart Int J Radiat Oncol Biol Phys 1990
No recovery between 1
day and 9 months after
initial treatment
Progression of
(subclinical) damage
results in shortening of
latent times after
retreatment
Extreme caution when
re-irradiating urinary
bladder!
Modified from Stewart FA & van der Kogel AJ
Semin Radiat Oncol
1994
0 20 40 60 80 100 120
0 20 40 60 80 100
0
20
40
60
80
100
0
20
40
60
80
100
120
Initial dose (% of EQD
tol
)
Reirradiation dose (% of EQD
tol
)
skin/oral mucosa
lung
pneumonitis
spinal cord
kidney
(bladder)
(heart?)
early effects
late effects
Summary experimental data