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Indications for post-operative radiotherapy in case after PST:
pTNM vs ypTNM
•
Buchholz et al., 2002 IJRBOP:
–
NO RT indicated based on
ypTNM
(N = 150)
–
NO RT indicated based on
pTNM
(N = 1031)
–
Results: 5 yr LRR 27% vs 15%, respectively, p = 0.001
•
Further analysis of the retrospective series:
–
Not only ypTNM but also cTNM stage prior to chemotherapy is
important:
•
Stage III prior to PST: 20% LRR, even after excellent response !
•
pts with pCR – high LRR rate : 33% !