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What about patients with cT1-2N0-1 disease ?
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cT1-2N0
ypT0-2 ypN0 after PST:
RT after MRM probably not required (SUPREMO trial to be awaited).
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cT1-2N1
ypT0-2 ypN0-1
Role of RT unclear;
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Some advocate LR- RT, since the cN1 might have been pN2 disease
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Some advocate LR- RT, since RT in cN+ improves OS
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Some advocate L(R) RT based on risk factors prior to chemo:
vascular invasion, grade; however, no reliable scoring on biopsy..?
Over- or undertreatment ?