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Indications for post-operative radiotherapy in case after PST
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Tumor biology AND initial stage AND response to chemotherapy are
probably the driving forces for a local recurrence (Mittendorf et al, 2013)
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RT is indicated if:
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RT was already indicated based on cTNM stage prior to chemotherapy:
Stage III and higher : cT3/4 and/or cN2/3
thus even in case of pCR !
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In patients with ypTNM stages T3-4 and/or N2-3.
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What about the patients with clinical stage T0-2N0-1 ?