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Omission of breast surgery after PST
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“Neoadjuvant Chemotherapy Followed by RT Alone in BC Patients”
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Study from Brazil: NCT03213925, phase 2 study
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If cCR on MRI: Only RT breast with boost
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Inclusion 2017 - 2020; Number of patients not given.
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Primary endpoint: IBTR at 5 yrs.
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NOSTRA trial UK
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RCT for ER negative Her2 positive patients with pCR:
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RT alone vs surgery with RT.
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First pilot aimed at
staging:
breast biopsies followed by surgery (Francis
et al, abstract Cancer Research 2017)