95
Biophysical Society 58
th
Annual Meeting, San Francisco, California
M
O
N
D
A
Y
1659-P
os
B
oard
#B389
ACIDOSIS: A POSSIBLE TRIGGER FOR BRUGADA
SYNDROME ASSOCIATED ARRHYTHMIA.
Colin H. Peters
,
Peter C. Ruben
1660-P
os
B
oard
#B390
INAL IN THE PATHOPHYSIOLOGY OF INSULIN-SECRETION:
A “CARDIAC” PARADIGM IN A NEW CELL TYPE.
Riccardo Rizzetto
, Marcella Rocchetti, Alice Villa, Luca Sala,
Carlotta Ronchi, Isabella Molinari, Mara Ferrandi, Antonio Zaza
1661-P
os
B
oard
#B391
REDUCTIONOF CARDIAC SODIUMCURRENT IS INDEPENDENT
OF CARDIAC HYPERTROPHY IN MICE WITH CARDIAC
SPECIFIC OVEREXPRESSION OF TYPE 1 ANGIOTENSIN II
RECEPTOR.
Sophie Mathieu
, Nabil El Khoury, Katy Rivard,
Mona Nemer, Céline Fiset
1662-P
os
B
oard
#B392
DIFFERENTIAL THERMOSENSITIVITY IN NAV1.5
MUTATIONS ASSOCIATED WITH LONG QT AND BRUGADA
SYNDROMES. Mena Abdelsayed,
Peter C. Ruben
1663-P
os
B
oard
#B393
TRAFFICKING DEFECTIVE MUTATIONS MODULATE NA
V
1.5
NGLYCOSYLATION STATES. Aurelie Mercier, Romain Clement,
Patrick Bois,
Aurelien Chatelier
1664-P
os
B
oard
#B394
SELECTIVE INHIBITION OF LATE NA
+
CURRENT REDUCES
ARRHYTHMIC ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE
RAT MYOCYTES.
Nesrine El-Bizri
, Steven Nguyen, Gongxin Liu,
Luiz Belardinelli, Sridharan Rajamani
1665-P
os
B
oard
#B395
DYNAMIC LATE NA CURRENT DURING CARDIAC ACTION
POTENTIAL REVEALED BY A SPECIFIC AND POTENT
INHIBITOR GS967. Zhong Jian, Balazs Horvath, Tamas Banyazs,
Leighton T. Izu, Yi-Je Chen, Sridharan Rajamani, Kenneth Ginsburg,
Julie Bossuyt, Donald M. Bers, Luiz Belardinelli,
Ye Chen-Izu
1666-P
os
B
oard
#B396
INCREASED ACTIVITY OF NAV1.9 SODIUM CHANNELS
CAUSES LOSS OF PAIN PERCEPTION.
Enrico Leipold
,
R. Oliver Goral, Stefan H. Heinemann, Christian A. Hübner, Ingo Kurth
1667-P
os
B
oard
#B397
EPILEPSY INCREASES THE CONTRIBUTION OF
TETRODOXIN-SENSITIVE CHANNELS TOTHE CARDIAC
SODIUM CURRENT. Michael Biet, Nathalie Morin, Sandra Duss,
Nathalie Sanon, Lionel Carmant,
Robert Dumaine
Voltage-gated Ca Channels II
(Boards #B398–#B417)
1668-P
os
B
oard
#B398
PROFILING MECHANISMS OF RGK INHIBITION ACROSS
THE FAMILY OF HIGH-VOLTAGE-ACTIVATED CAV1/CAV2
CALCIUM CHANNELS.
Akil A. Puckerin
, Donald D. Chang,
Henry M. Colecraft
1669-P
os
B
oard
#B399
LEUCINE-RICH REPEAT CONTAINING 10 (LRRC10) PROTEIN
IS A NOVEL REGULATOR OF CARDIAC CAV1.2 L-TYPE
CALCIUM CHANNELS.
Courtney R. Reynolds
, Li Feng,
Matthew J. Brody, Lee Youngsook, Ravi C. Balijepalli
1670-P
os
B
oard
#B400
A UNIFIED FRAMEWORK FOR CALCIUM CHANNEL
MODULATION BY CALCIUM BINDING PROTEINS.
Philemon S. Yang, Manu Ben Johny,
David T. Yue
1671-P
os
B
oard
#B401
C-TERMINAL MODULATION OF CAV1.3 L-TYPE CALCIUM
CHANNELS MODIFIES THEIR GATING PROPERTIES IN
COCHLEAR INNER HAIR CELLS. Stephanie Eckrich, Anja Scharinger,
Stefan Muenkner
, Kai Schönig, Amy Lee, Dusan Bartsch, Alexandra Koschak,
Martina Sinnegger-Brauns, Dietmar Hecker, Bernhard Schick,
Joerg Striessnig, Jutta Engel
1672-P
os
B
oard
#B402
USING EXOFACIALLY TAGGED FUNCTIONAL CAV2.2 TO
INVESTIGATE THE MODULATION OF PORE SUBUNIT
TRAFFICKING BY AUXILIARY CALCIUM CHANNEL SUBUNITS.
John S. Cassidy
, Annette C. Dolphin
1673-P
os
B
oard
#B403
CARDIOMYOCYTE ENDPOINTS DISTINGUISHNON-CANONICAL
REGULATION OF THE RGK GTPASES RAD AND REM.
Donald D. Chang
, Henry M. Colecraft
1674-P
os
B
oard
#B404
DIFFERENTIAL CA
V
2.1 AND CA
V
2.3 CHANNEL INHIBITION BY
BACLOFEN AND
α
-CONOTOXIN VC1.1 VIA GABA
B
RECEPTOR
ACTIVATION.
Geza Berecki
, Jeffrey R. McArthur, Hartmut Cuny,
Richard J. Clark, David J. Adams
1675-P
os
B
oard
#B405
CALORIMETRIC AND NMR CHARACTERIZATION OF A REM2
G-DOMAIN INTERACTION WITH THE SH3-GK CORE OF THE
CA
2+
CHANNEL BETA4 SUBUNIT.
Xingfu Xu
, William A. Horne
1676-P
os
B
oard
#B406
A TIMOTHY SYNDROME CAUSING MUTATION PERTURBS
VOLTAGE SENSOR OPERATION INHUMAN CA
V
1.2 CHANNELS.
Nicoletta Savalli
, Antonios Pantazis, Daniel Sigg, Alan Neely, Riccardo Olcese
1677-P
os
B
oard
#B407
THREE SPLICE VARIANTS OF THE CALCIUM CHANNEL BETA4
SUBUNIT DISPLAY DIFFERENTIAL TARGETING AND GENE
REGULATION IN NEURONS. Solmaz Etemad, Gerald J. Obermair,
Verena Burtscher, Daniel Bindreither,
Bernhard E. Flucher
1678-P
os
B
oard
#B408
IDENTIFICATION OF A DETERMINANT OF HIGH AFFINITY
CALCIUM BINDING IN THE SELECTIVITY FILTER OF A
MAMMALIAN CALCIUM CHANNEL.
Felix Findeisen
, David Shaya,
Fayal Abderemane-Ali, Cristina Arrigoni, Gildas Loussouarn,
Daniel L. Minor, Jr.
1679-P
os
B
oard
#B409
FUNCTIONAL CLUSTERING OF L-TYPE CAV1.3 CHANNELS.
Claudia M. Moreno
, Rose E. Dixon, Can Yuan, Marc D. Binder,
Luis F. Santana
1680-P
os
B
oard
#B410
CALCIUM CHANNEL
α
2
δ
-1 SUBUNIT KNOCKOUT CAUSES
DIABETES DUE TO IMPAIRED INSULIN RELEASE.
Petronel Tuluc
, Vincenzo Mastrolia, Mathias Drach, Sylvia M. Flucher,
Erik Renström, Jörg Striessnig, Bernhard E. Flucher
1681-P
os
B
oard
#B411
CHEMICAL-BIOLOGICAL GENERATOR OF STEP INCREASES IN
CALMODULIN REVEALS DUAL MODULATION OF L-TYPE CA
2+
CHANNELS.
Paul Adams
, Manu Ben Johny, Ivy E. Dick, David T. Yue
