98
Biophysical Society 58
th
Annual Meeting, San Francisco, California
1730-P
os
B
oard
#B460
DIRECT INTERACTION OF RIC-3 WITH THE INTRACELLULAR
DOMAIN OF EUKARYOTIC CATIONIC PENTAMERIC
LIGAND-GATED ION CHANNELS.
Sita Nirupama Nishtala
,
Nelli Mnatsakanyan, Michaela Jansen
1731-P
os
B
oard
#B461
THE PROKARYOTE LIGAND-GATED ION CHANNEL ELIC
CAPTURED IN A PORE BLOCKER-BOUND CONFORMATION
BY THE ALZHEIMER’S DISEASE DRUG MEMANTINE.
Chris Ulens,
Radovan Spurny
, Andrew J. Thompson, Mona Alqazzaz,
Sarah Debaveye, Han Lu, Kerry Price, Jose M. Villalgordo,
Gary Tresadern, Gary Tresadern, Joseph W. Lynch, Joseph W. Lynch,
Sarah C. R. Lummis
1732-P
os
B
oard
#B462
PROBING PENTAMERIC LIGAND-GATED ION CHANNELS
WITH BROMOFORM REVEALS MANY INTERCONNECTED
ANESTHETIC BINDING SITES. Benoist Laurent,
Samuel Murail
,
Ludovic Sauguet, Marc Delarue, Marc Baaden
1733-P
os
B
oard
#B463
MOLECULAR INSIGHTS INTO THE GATING MECHANISM
OF GLIC, A PROKARYOTIC LIGAND-GATED ION CHANNEL.
Mehrnoosh Arrar
, Iman Pouya, James Andrew McCammon,
Erik Lindahl
1734-P
os
B
oard
#B464
LIGAND-GATED ION CHANNEL GATING KINETICS AND
THE OPENING/CLOSING MECHANISM ARE SENSITIVE TO
MUTATIONS ALTERING THE HYDROPHOBICITY OF THE ION
CONDUCTION PORE.
Goran Klement
, Iman Pouya, Özge Yoluk,
Rebecca Howard, Erik Lindahl
1735-P
os
B
oard
#B465
ALTERING THE OPEN VS. CLOSED STATE BALANCE OF THE
GLIC LIGAND-GATED ION CHANNELTHROUGHMUTAGENESIS
ENABLES MOLECULAR SIMULATION OF THE REVERSIBLE
GATING PROCESS. Iman Pouya, Göran Klement, Samuel Murail,
Peter Kasson, Özge Yoluk,
Erik Lindahl
1736-P
os
B
oard
#B466
STRUCTURAL BASIS FOR ALLOSTERIC TRANSITIONS IN
THE GLIC PENTAMERIC PROTON-GATED ION CHANNEL.
Ludovic Sauguet
, Azadeh Shahsavar, Frederic Poitevin, Christele Huon,
Anais Menny, Akos Nemecz, Ahmed Haouz, Jean-Pierre Changeux,
Pierre-Jean Corringer, Marc Delarue
Cardiac Muscle I (Boards #B467–#B498)
1737-P
os
B
oard
#B467
EFFECT OF PIMOBENDAN ON HEART FAILURE IN A MOUSE
MODEL INHERITED CARDIOMYOPATHY.
Miki Nonaka
,
Kengo Hayamizu, Sachio Morimoto
1738-P
os
B
oard
#B468
EFFECTS OF CHRONIC MYOCARDIAL INFARCTION ON
CARDIACMUSCLE PERFORMANCE AND STRUCTURE IN-VIVO
AND IN-VITRO.
Christopher Toepfer
, Markus Sikkel, Valentina Caorsi,
O’Neal Copeland, Iratxe Torre Martinez, Timothy West, Steve Marston,
Pradeep Luther, Alexander Lyon, Kenneth Macleod, Michael Ferenczi
1739-P
os
B
oard
#B469
ELUCIDATING THE ROLE OF MYOSIN PSEUDO-
PHOSPHORYLATION IN A NOVEL RESCUE MOUSE MODEL
OF CARDIOMYOPATHY.
Priya Muthu
, Chen-Ching Yuan,
Katarzyna Kazmierczak, Jingsheng Liang, Ana Isabel Rojas,
Danuta Szczesna-Cordary
1740-P
os
B
oard
#B470
AGE-RELATED CARDIAC DYSFUNCTION IN TRANSGENIC
MICE CARRYING ACTIN E99K MUTATION.
Li Wang
,
Weihua Song, Andrew Messer, Steven Marston, Masataka Kawai
1741-P
os
B
oard
#B471
DETAILED HEMODYNAMIC CHARACTERIZATION OF
ATHLETE’S HEART USING LEFT VENTRICULAR PRESSURE-
VOLUME ANALYSIS IN A RAT MODEL.
Dalma Kellermayer
,
Attila Oláh, Árpád Lux, Balázs Tamás Németh, László Hidi, Ede Birtalan,
Mihály Ruppert, Csaba Mátyás, Béla Merkely, Tamás Radovits
1742-P
os
B
oard
#B472
INCORPORATION OF TROPONIN C WITH MODIFIED CA
2+
BINDING INTO THE HEART THROUGH THE USE OF
ADENO-ASSOCIATED VIRUS LEADS TO ALTERED HEART
FUNCTION. Vikram Shettigar, Sean C. Little, Jianchao Zhang,
Steve R. Roof, Mark T. Ziolo, Brandon J. Biesiadecki,
Jonathan P. Davis
1743-P
os
B
oard
#B473
CROSSING MICE CARRYING TNT DISEASE MUTATIONS
WITHOPPOSITE EFFECTS ONTHE MYOFILAMENT CALCIUM
SENSITIVITY PARTIALLY NORMALIZES MYOFILAMENT
FUNCTION AND AMELIORATES CARDIOMYOPATHY
PHENOTYPES.
Rajdeep S. Turna
, Rebecca S. Weller,
Hyun-Seok Hwang, David Dweck, Ferhaan Ahmad, Sabine Huke,
Björn C. Knollmann, Jose Renato Pinto
1744-P
os
B
oard
#B474
IMPACT OF E163R CTNT MUTATION ON CARDIAC MECHANICS
AND ENERGETICS IN A MURINE MODEL.
Benedetta Tosi
,
Cecilia Ferrantini, José Manuel Pioner, Claudia Ferrara, Beatrice Scellini,
Nicoletta Piroddi, Salwa Abdullah, Coppini Raffaele, Sara Bardi,
Jill Tardiff, Chiara Tesi, Corrado Poggesi
1745-P
os
B
oard
#B475
AAV6-MEDIATED OVEREXPRESSION OF RIBONUCLEOTIDE
REDUCTASE (R1R2) ENHANCES 2-DEOXY-ATP CONCENTRATION
IN VIVO AND IMPROVES CARDIAC FUNCTION.
Elizabeth Gay
,
Sarah G. Nowakowski, Stephen C. Kolwicz, Guy L. Odom,
Galina V. Flint, Rudy Stuppard, Haiwei Gu, Jeffrey S. Chamberlain,
Daniel Raftery, Rong Tian, David J. Marcinek, Michael Regnier
1746-P
os
B
oard
#B476
TITIN-BASED PASSIVE TENSION IS INCREASED IN A TITIN AI
KO MOUSE.
Rebecca Slater
, Kirk Hutchinson, Mei Methawasin,
Henk L. Granzier
1747-P
os
B
oard
#B477
MYOCARDIAL TITIN: AN IMPORTANT MODIFIER OF
CARDIAC STIFFNESS.
Nazha Hamdani
, Wolfgang A. Linke
1748-P
os
B
oard
#B478
A GAIN-OF-FUNCTION MUTATION IN CARDIAC MYOSIN
BINDING PROTEIN-C INCREASES VISCOELASTIC LOAD
AND SLOWS SHORTENING VELOCITY IN MYOCYTES FROM
TRANSGENIC MICE.
Kristina L. Bezold
, Jaskiran K. Khosa,
Samantha P. Harris
1749-P
os
B
oard
#B479
EXERCISE-INDUCED ENHANCEMENT OF CARDIAC AND
SARCOMERE PERFORMANCE IS LARGER IN MALE THAN
IN FEMALE MYBPC3 MUTATION HETEROZYOUS KNOCK-IN
MICE.
Aref Najafi
, Saskia Schlossarek, Elza van Deel,
Nikki van den Heuvel, Ahmet Güçlü, Max Goebel, Nicky Boontje,
Diederik Kuster, Lucie Carrier, Jolanda Van der Velden
