99
Biophysical Society 58
th
Annual Meeting, San Francisco, California
M
O
N
D
A
Y
1750-P
os
B
oard
#B480
GENDER DIFFERENCES IN PASSIVETENSION IN
HYPERTROPHIC CARDIOMYOPATHY PATIENTS.
Louise L.A.M. Nijenkamp
, Jessica A. Regan, Michelle Michels,
Chris dos Remedios, Carolyn H. Ho, Jolanda van der Velden
1751-P
os
B
oard
#B481
SEX-RELATED DIFFERENCES IN MYOSIN HEAVY CHAIN
ISOFORMS OF HUMAN FAILING AND NON-FAILING ATRIA.
Peter J. Reiser
, Christine S. Moravec
1752-P
os
B
oard
#B482
MYOCARDIAL INFARCTION-INDUCED N-TERMINAL
FRAGMENT OF CMYBP-C IMPAIRS MYOFILAMENT
FUNCTION IN HUMAN LEFT VENTRICULAR MYOFIBRILS.
Namthip Witayavanitkul
, Jason Sarkey, Younss Aitmou,
Diederik W.D. Kuster, Ramzi J. Khairallah, Suresh Govindan,
Xin Chen, Ying Ge, Sudarsan Rajan, David F. Wieczorek,
Thomas Irving, Pieter P. de Tombe, Sakthivel Sadayappan
1753-P
os
B
oard
#B483
BETA-ADRENERGIC RESPONSE IN HUMAN HCM
MYOCARDIUM: EFFECTS OF RANOLAZINE.
Cecilia Ferrantini
,
Raffaele Coppini, Benedetta Tosi, Josè Manuel Pioner, Laura Sartiani,
Iacopo Olivotto, Chiara Tesi, Luiz Belardinelli, Elisabetta Cerbai,
Alessandro Mugelli, Corrado Poggesi
1754-P
os
B
oard
#B484
DEPRESSED CONTRACTILITY AT LOW-LOAD
SPONTANEOUS OSCILLATORY CONTRACTIONS IN
HUMAN HYPERTROPHIC CARDIOMYOPATHY WITH
MYBPC3 MUTATIONS.
Amy Li
, J. Martijn Bos,
Michael J. Ackerman, Filip Braet, Murat Kekic, Shin’ichi Ishiwata,
Cristobal G. dos Remedios
1755-P
os
B
oard
#B485
THE ROLE OF CARDIAC MYOSIN LIGHT CHAIN 2V
PHOSPHORYLATION IN THE HEALTHY AND FAILING
MYOCARDIUM.
Ramzi J. Khairallah
, Namthip Witayavanitkul,
Mohit Kumar, Mengjie Zhang, Pieter de Tombe
1756-P
os
B
oard
#B486
EXISTENCE OF LENGTH-DEPENDENT MODULATION OF
CROSS-BRIDGE CYCLING KINETICS IN RIGHT VENTRICLES
OF NON-FAILING AND FAILING HUMAN MYOCARDIUM.
Nima Milani-Nejad
, Jonathan P. Davis, Vadim V. Fedorov,
Peter J. Mohler, Ahmet Kilic, Robert S.D. Higgins, Paul M.L. Janssen
1757-P
os
B
oard
#B487
INCREASED CAMKII ACTIVITY IMPAIRS CONTRACTILE
FUNCTION IN HUMAN HCM MYOCARDIUM.
Raffaele Coppini
, Cecilia Ferrantini, Manuel J. Pioner, Lina Yao,
Peidong Fan, Benedetta Tosi, Elisabetta Cerbai, Luiz Belardinelli,
Chiara Tesi, Corrado Poggesi
1758-P
os
B
oard
#B488
THE CARDIAC TROPONIN T R92L HCM MUTATION
ALTERS CARDIACTROPONIN I DYNAMICS AND PKA
PHOSPHORYLATION POTENTIAL.
Jayant James Jayasundar
,
Kenneth Brooks, Sarah Lehman, Michael R. Williams, Jil C. Tardiff
1759-P
os
B
oard
#B489
CONFORMATIONAL AND FUNCTIONAL EFFECTS OF
PATHOGENIC MUTATIONS AT THE I-T INTERFACE OF
CARDIAC TROPONIN I.
Shirin Akhter
, J. -P Jin
1760-P
os
B
oard
#B490
COMPUTATIONAL PREDICTION AND EXPERIMENTAL
VERIFICATION OF DIFFERENTIAL CALCIUM AFFINITY
IN THIN FILAMENT MUTANTS KNOWNTO CAUSE
HYPERTROPHIC CARDIOMYOPATHY. Edward P. Manning,
Sarah J. Lehman
, Steven D. Schwartz, Jil C. Tardiff
1761-P
os
B
oard
#B491
CA
2+
-INDUCED STRUCTURAL CHANGES INTN: A MULTI-SITE
FRET STUDY COMBININGTCSPCWITH SINGLE FILAMENT
IMAGING.
Maria E. Moutsoglou
, Gi-Ho Kim, Christopher Solis-Ocampo,
Steven C. Wu, John M. Robinson
1762-P
os
B
oard
#B492
PARTIAL ACTIVATION OF THE CARDIAC MYOFILAMENT
BY CA
2+
.
Mathivanan Chinnaraj
1763-P
os
B
oard
#B493
MODULATION OF THE INTERACTION BETWEEN
TROPONIN I N-TERMINAL PEPTIDE AND TROPONIN
C BY PHOSPHORYLATION STUDIED BY MOLECULAR
DYNAMICS. Ian Gould, Andrew E. Messer, Maria Papadaki,
Steven B. Marston
1764-P
os
B
oard
#B494
CARDIAC TROPONIN I A164H AND PH-DEPENDENT
INOTROPY.
Anthony D. Vetter
, Brian Thompson,
Joseph M. Muretta, David D. Thomas, Joseph M. Metzger
1765-P
os
B
oard
#B495
MOLECULAR MECHANISM OF CARDIOMYOPATHY-CAUSING
MUTATIONS IN ALPHA-TROPOMYOSIN.
Tejas M. Gupte
,
Farah Haque, Binnu Gangadharan, Margaret Sunitha, Suman Nag,
Sowdhamini R, VijayRaghavan K, James A. Spudich, John A. Mercer
1766-P
os
B
oard
#B496
SKELETAL MUSCLE MYOPATHY MUTATIONS INTROPOMYOSIN
GENETPM3 AFFECTTHIN FILAMENTTRANSITIONS BETWEEN
THE INACTIVE AND ACTIVE STATES.
Mohammed El-Mezgueldi,
Saeed Asiri, Widad Albishri, Kristen Nowak
1767-P
os
B
oard
#B497
DIRECT VISUALIZATION OF COOPERATIVE BINDING
OF TROPONIN-TROPOMYOSIN TO F-ACTIN.
Christopher Solis-Ocampo
, Maria Moutsoglou, Gi-Ho Kim,
John M. Robinson
1768-P
os
B
oard
#B498
THE ACCURACY OF CARDIAC MYOFILAMENT SIMULATIONS
IS ENHANCED BY PERMITTING CALCIUM-INDEPENDENT
TROPOMYOSIN TRANSITIONS. Yasser Aboelkassem,
Kimberly McCabe,
Stuart G. Campbell
Microtubules, Their Motors and
Associated Proteins I (Boards #B499–#B524)
1769-P
os
B
oard
#B499
TUBULIN HETERODIMERS REVERSIBLY DISSOCIATE WITH
MODERATE KINETICS AS DEMONSTRATED USING SEDI-
MENTATION VELOCITY ANALYTICAL ULTRACENTRIFUGA-
TION.
Felipe Montecinos-Franjola
, Dan L. Sackett, Peter Schuck
1770-P
os
B
oard
#B500
STUDYING THE STRUCTURAL ORIGINS OF MICROTUBULE
DYNAMIC INSTABILITY THROUGH COMBINING COMPU-
TATIONAL MODELING AND CRYOEM.
Elizabeth H. Kellogg
,
Gregory M. Alushin, Gabriel C. Lander, David Baker, Eva Nogales
