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Opioid tolerance in advanced cancer patients
Open label multicenter study (Fen-Bel 5 study)
compassionate use TTS-fentanyl in Belgium (59 physicians)
Palliative untreatable cancer patients
with a assessed life expectancy of ≥ 3 months
that need opioids for pain relief could be included (inform. cons)
After stabilisation (14d) on oral morphine
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VAS-score <3,5
Change of morphine
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equivalent dose TTS-fentanyl,
oral morphine is free available for break through pain (BTP)
Dose fentanyl is up-titrated if oral morphine ≥ 60mg/d for BT
Aim of the study: compliance + side effects of TTS fentanyl