774 / 1096
S758
ESTRO 36
_______________________________________________________________________________________________
pixels was around 0.3 %. Overlap analysis yielded a mean
DC of 0.99 with SD 0.002 which translates in an excellent
agreement. HD calculation resulted in a mean distance of
6.02 mm and a SD of 3.42 mm. For all cases the algorithm
was able to successfully separate the body from adjacent
parts like breathing belt, blankets, mattress etc. (see
figure).
Conclusion
We have presented a fully automatic algorithm for body
delineation on CT that can handle structures adjacent to
the patient. It has been evaluated in a clinical setting,
showing an outstanding performance. Particularly, 30
clinical cases including several body locations were
segmented. Evaluation demonstrated an excellent
agreement with respect to reference contours. For
segmentation no user interaction is required. Results
suggest the suitability of the algorithm for clinical use with
cases of the tested region between thorax and pelvis.
Future work will explore the use of the algorithm for other
body
regions.
EP-1418 RandOmized Study Exploring the combination
of radioTherapy with Two types of Acupuncture
treatment
R. Asadpour
1
, K. Kessel
1,2
, D. Habermehl
1
, T. Bruckner
3
,
S. Sertel
4
, S. Combs
1,2
1
Technical Universy Munich TUM, Department of
Radiation Oncology, München, Germany
2
Institute of Innovative Radiotherapy iRT, Department of
Radiation Sciences DRS, Neuherberg, Germany
3
Institute of Medical Biometry and Informatics IMBI,
Department of Medical Biometry, Heidelberg, Germany
4
Bâtiment hospitalier, Department of ORL and Cervical
Surgery, Lausanne, Switzerland
Purpose or Objective
Acupuncture is known to reduce various clinical signs and
symptoms. Often patients treated with radiation therapy
(RT) suffer from side effects such as fatigue,
nausea/vomiting or reduction of quality of life (QoL). Few
randomized data are available to define the role of
acupuncture in the context of radiation oncology as a
supporting treatment. Therefore, the ROSETTA
(
R
and
O
mized
S
tudy
E
xploring the combination of
radio
T
herapy with
T
wo types of
A
cupuncture treatment)
trial was initiated as a prospective randomized phase II
trial. It examines if traditional (verum-) acupuncture can
reduce RT-related side effects significantly in comparison
to sham (false-) acupuncture.
Material and Methods
A total of 74 patients are to be recruited. In the
experimental arm (n=37) an experienced acupuncture-
trained person will treat dedicated acupuncture points. In
the control arm (n=37) sham-acupuncture will be
performed to provide a blinded comparison of results. The
Ethics Committee of the Technical University of Munich
(TUM) approved the nature and content of the study with
the project number 512/15.
To evaluate quality of life, patients receive a standardized
questionnaire (EORTC QLQ C-30) before their first, after
their fourth and after their last acupuncture treatment.
Further, a study investigator questions patients about
their feelings and symptoms as well as documents detailed
information regarding their course of disease. The main
endpoint of the trial is the improvement of QoL and
reduction of fatigue. Secondary endpoints are the
reduction of RT-related side effects such as headache,
nausea, and pain.
Results
The ROSETTA trial is currently recruiting. Initial results
from 30 patients (verum acupuncture n=15; sham
acupuncture n=15) are presented. All the following items
are scaled from 0 to 100. A high score in a symptom scale
represents an aggravation of symptoms, whereas a high
score in QoL shows an improvement.
Concerning nausea/vomiting and QoL no significant
difference can be observed between the sham-
acupuncture and the verum group. Thus, patients suffer
from a constant level of these side effects during RT. From
the first examination to the last visit, fatigue increases in
the group receiving sham acupuncture (from 21 to 44).
Meanwhile, fatigue remains constant in the verum group
(from 40 to 40). Verum-acupuncture shows positive effects
in reduction of pain (first visit: 21, last visit: 25) in
comparison to the sham-acupuncture group (first visit: 23,
last visit: 30).
Conclusion
We present first results of the ROSETTA trial, which show
preliminary tendencies in 30 randomized patients.
Comparing the verum and the sham-acupuncture group,
some differences regarding fatigue and pain are apparent.
In spite of undergoing RT, patients in both groups do not
feel worse concerning the examined features. Our results
and ongoing research will generate an excellent data basis
on how to include certain complementary medicine
methods into high-end oncology treatment.
EP-1419 Optimal design and patient selection for
interventional trials using radiogenomic biomarkers
D. De Ruysscher
1
, G. Defraene
2
, B. Ramaekers
3
, P.
Lambin
4
, E. Briers
5
, H. Stobart
6
, T. Ward
7
, S. Bentzen
8
, T.
Van Staa
9
, S. Kerns
10
, C. West
11
1
MAASTRO Clinic, Radiation Oncology, Maastricht, The
Netherlands
2
KU Leuven, Radiation Oncology, Leuven, Belgium
3
Maastricht University Medical Center, Department of
Clinical Epidemiology and Medical Technology
Assessment, Maastricht, The Netherlands
4
Maastricht University Medical Center, GROW School for
Oncology and developmental Biology- Department of
Radiation Oncology MAASTRO Clinic, Maastricht, The
Netherlands
5
Patient Advocate, Patient Advocate, Hasselt, Belgium
6
Patient Advocate, Patient Advocate, Cambridge, United
Kingdom
7
Patient Advocate, Patient Advocate, Manchester, United
Kingdom
8
University of Maryland, School of Medicine, Baltimore,
USA
9
University of Manchester, Manchester Academic Health