776 / 1096
S760
ESTRO 36
_______________________________________________________________________________________________
to 5 cc (31.6%), and > 5cc (32,5%). Mean margin dose 15
Gy ( 12-18 Gy) and the maximal 30 Gy
Results
PF
Obliteration
PF<1: complete 60% , partial 35%, no change 4.5%; PF
1.01-1.5: complete 43.5%, partial 47.5% , no change 9%;
PF 1.51-2: complete 45%, partial 50%, no change 5%; PF
> 2: 1.5% complete, partial 78.5%, no change 6.1%.
Rebleeding
PF <1: 2.4%; PF 1.01-1.5: 3%; PF 1.51-2: 3.8% and PF >
2 had no rebleeding,
Toxicity
PF <1: acute 13.5%, late 10,6% (clinical 4.7% radiological
3.5%, radiological and clinical 2.4%); PF 1.01-1.5: acute
16%, late 13% (clinical 8%, radiological 2%, clinical and
radiological 3%); PF 1.51-2: acute 11.5%, late 12%
(clinical 5%, radiological 3.5%, radiological and clinical
3.5%); PF > 2 : acute 17.5%, late 21% (clinical 18%,
clinical and radiological
toxicity 3%)
SM
Obliteration
Grade I: complete 65%, partial 35%; Grade II: 50%
complete, partial 45%, no change 5%; Grade III:
complete 46% , partial 46% ,no change 8%; Grade IV :
complete 17% , partial 72 % , no change 11%, and Grade
V: any complete obliteration.
Rebleeding
Grade I: 5%, Grade II: 1,4%, Grade III: 3%, Grade IV: 13.%,
Grade V no rebleeding.
Toxicity
Grade I: acute 12.5%, late 8.6% (clinical 4.3% ,
radiological 4.3%); Grade II: acute 3.7% , late 14%
(clinical 7.5%, radiological 4%, radiological and clinical
2.5%); Grade III: acute 19.5 % , late 14%(clinical
4% radiological 3%, clinical and radiological 7%); Grado
IV: acute 21%, late 29.5% (clinical 23.5 %, radiological
and clinical 6%); Grade V: acute 100%, and no late
Conclusion
The experience of this single Institution are consistent
with those published in the literature , low rate of
rebleeding, acceptable toxicity, and obliteration rate
that varies with the nidus size and the prognostic factors
according to the (SM) and the (PF)
EP-1422 Pregnancy outcomes in cancer patients
received radiotherapy: a nationwide population-based
study
Y.J. Chiang
1
1
Chang Gung Memorial Hospital- Linkou, Department of
Radiation Oncology, Taoyuan, Taiwan
Purpose or Objective
To estimate the risks of adverse maternal outcomes in
female cancer patients received radiotherapy (RT)
compared with women without malignancy.
Material and Methods
We identified 2,350,335 singleton pregnancy using Taiwan
National Health Insurance Database and Taiwan Birth
Registry between 2001 and 2012, of which 607 pregnancies
were in female cancer patients with RT. Odds ratios (ORs)
and 95% confidence intervals (CIs) for maternal outcomes
were estimated using generalized estimating equation
model adjusted by maternal age, Charlson comorbidity
index, urbanization, income, occupation and birth of year.
Results
From 2001 to 2012, pregnancies in female cancer patients
received radiotherapy were associated with an adjusted
OR (95% CIs) of 1.46 (1.02-2.09) for severe postpartum
hemorrhage compared with women without malignancy.
Otherwise there were no significant increasing risks with
an adjusted OR of 0.95 (0.84-1.07) for Caesarean section,
0.56 (0.39-0.80) for preterm labor, 0.84 (0.64-1.11) for
antepartum hemorrhage, 0.48 (0.32-0.74) for pregnancy
related hypertension, 0.60 (0.38-0.95) for preeclampsia,
and 0.62 (0.46-0.85) for gestational diabetes.
Conclusion
For female cancer patients received radiotherapy, the risk
of severe postpartum hemorrhage might be increased.
EP-1423 the evaluation of sleep quality in cancer
patients following the diagnosis of a metastatic site
E. Yirmibesoglu Erkal
1
, D. Celik
1
, S. Ozmen
1
, G. Aksu
1
,
H.S. Erkal
2
1
Kocaeli University, Department of Radiation Oncology,
Kocaeli, Turkey
2
Sakarya University, Department of Radiation Oncology,
Sakarya, Turkey
Purpose or Objective
The aim of this study was the evaluate the sleep quality in
cancer patients receiving palliative radiotherapy for the
first time following the diagnosis of a metastatic site and
to correlate the sleep quality with the depression status
and the level of hopelessness.
Material and Methods
Forty-eight metastatic cancer patients about to receive
palliative radiotherapy were evaluated using
questionnaires for Pittsburgh Sleep Quality Index (PSQI),
Beck Depression Inventory (BDI) and Beck Hopelessness
Scale (BHS). There were 12 females and 36 males, their
ages ranging from 27 to 77 years (median, 60 years). 39
patients were married and 14 patients had at least high
school education. Primary tumor site was listed as the
respiratory system in 14 patients and the genitourinary
system in 14. The time from the diagnosis of cancer to the
diagnosis of the metastatic site was less than 1 month in
17 patients, 1 to 6 months in 10 and over 6 months in 21.
Radiotherapy was delivered for bone metastases in 34
patients and brain metastases in 9.
Results
PSQI scores ranged from 0 to 17 (median, 10) and those
with scores over 8 were classified as poor sleepers. BDI
scores ranged from 0 to 36 (median, 15) and those with
scores over 10 were classified as having mild to severe
depression. BHS scores ranged from 0 to 16 (median, 4)
and those with scores less than 4 were classified as having
no hopelessness at all. Accordingly, there were 30 patients
who were poor sleepers, 29 who had mild to severe
depression and 25 who were hopeless. There was a strong,
positive correlation between PSQI scores and BDI scores
which was statistically significant (p=0.002). There was no
correlation between PSQI scores and BHS scores. There
was a statistically significant association between poor
sleep quality and single marital status (p=0.04).
Conclusion
Self-administered measurements such as PSQI, BDI and
BHS might be used as a simple means to collect data on
multiple facets of the sleep quality, the depression status
and the level of hopelessness. In this study, poor sleepers
were prevalent among metastatic cancer patients. Poor
sleep, associated with mild to severe depression, deserves
adequate medical attention in terms of supportive care
EP-1424 Fertility preserving high precision
radiotherapy in non-uterine pelvic malignancies in
female
P.S. Sridhar
1
, N. Madhusudhan
1
, K. Roopesh
1
, J. Vijay
kumar
1
, M. Praveen kumar
1
, A. Jerrin
1
, A. Pichandi
1
, B.
Ajai kumar
1
1
Health Care Global Enterprises Ltd, Cyberknife-
Radiation oncology, Bangalore, India
Purpose or Objective
Fertility is major issue in non-uterine pelvic malignancies
in reproductive age requiring radiation. Primary pathology