Dose Course Book

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Prescribed dose

Action limits - Proposed philosophy

Step 3:

Adjust the

true dose probability distribution

such that the dose

limits

IDC-C

α

/2

and

IDC+C

α

/2

coincide with the

clinical tolerance

limits.

Dose (Gy)

Probability distribution

for the true dose

Clinical tolerance

limits

−∆

TL

+∆

TL

is set to a minimum

acceptable cure rate

is set to a maximum

acceptable complication rate

From Jörgen Olofsson (Dose Modeling and dose verification ESTRO COURSE)