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Table 1.
Characteristics of the Included Studies.
Study Title
Author (Year)
Country
Patients, n Study Type
Diagnostic Criteria
‘‘Treatment of Meniere’s
Disease with
Hydrochlorothiazide’’
Norell and Stahle (1962)
18
Sweden
57 RCS
Internal/independent
criteria
‘‘Experiences with Acetazolamid
Therapy Applied in Our Clinic
to Patients Suffering from
Me´nie`re’s Disease for More
Than 8 Years’’
Varga et al (1966)
22
Hungary
60 RCS
Internal/independent
criteria
‘‘Menie´re’s Disease and
Hydrochlorothiazide
(Dichlotride ): A Critical
Analysis of Symptoms and
Therapeutic Effects’’
Klockhoff and
Lindblom (1967)
8
Sweden
30 RCTwith placebo Internal/independent
criteria
‘‘Diuretic Treatment of Meniere
Disease: Long-Term Results
with Chlorthalidone’’
Klockhoff
et al (1974)
16
Sweden
34 RCS
Not reported
‘‘Long-term Therapy of
Meniere’s Disease:
Comparison of the Effects of
Betahistine Dihydrochloride
and Hydrochlorothiazide’’
Petermann et al (1982)
10
Germany
32 RCT, no
placebo
Internal/independent
criteria
‘‘Treatment of Meniere’s
Disease with Isosorbide’’
Kitahara et al (1982)
9
Japan
102 RCTwith
controls
Internal/independent
criteria
‘‘Menie`re’s Disease and
Isosorbide as an Oral
Hyperosmotic Agent’’
Yamazaki et al (1982)
23
Japan
21 RCS
Japan Society for Equilibrium
Research for Me´nie`re’s disease
‘‘Oral Acetazolamide in
Meniere’s Disease’’
Brookes and
Booth (1984)
12
England
14 RCS
1972 AAOO Me´nie`re’s
guidelines
‘‘Use of a Diuretic
(Dyazide ) in the Treatment
of Me´niere’s Disease’’
van Deelen and
Huizing (1986)
11
Netherlands
33 RCTwith
placebo
Internal/independent
criteria
‘‘Long-term Effect of
Acetazolamide and
Chlorthalidone on the Hearing
Loss of Meniere’s Disease’’
Corvera and
Corvera (1989)
24
Mexico
192 Case-control
Internal/independent
criteria
‘‘Evaluation of a Three-Stage
Management Program for
Meniere’s Disease’’
Raivio et al (1989)
20
Sweden
104 RCS
1972 AAOO Me´nie`re’s
guidelines
‘‘Diuretic and Diet Effect on
Meniere’s Disease Evaluated by
the 1985 Committee on
Hearing and Equilibrium
Guidelines’’
Santos et al (1993)
21
US
54 RCS
1985 AAO-HNS guidelines
‘‘Effects of Isosorbide in Patients
with Meniere’s Disease’’
Kanda et al (1993)
14
Japan
32 RCS
1985 AAO-HNS guidelines
‘‘Effect of Isosorbide on Hearing
Loss due to Endolymphatic
Hydrops’’
Kakigi et al (1995)
26
Japan
103 RCS
Japan Society for Equilibrium
Research Society for Me´nie`re’s
Disease
‘‘Efficacy of Long-term
Administration of Isosorbide
for Meniere’s Disease’’
Nozawa et al (1995)
19
Japan
30 RCS
1972 AAOO Me´nie`re’s
guidelines
‘‘Use of Nimodipine in the
Medical Treatment of
Lassen et al (1996)
17
Italy
12 RCS
1972 AAOO Me´nie`re’s
guidelines
(continued)
Crowson et al
26