50 / 264
Table 3.
(continued)
Study
Outcome Measures
Hearing Result
Vertigo Result
Side Effects
Study Quality
Petermann et al
(1982)
10
Symptomatology, PTA Slight improvement of
hearing only during
the first 3 mo of
treatment
6 of 7 during the first
3 mo of treatment
noted improvement
in vertigo frequency
Hypokalemia,
hyperuricemia
2b
Kitahara et al (1982)
9
Symptomatology
None reported
Improved dizziness in
71%, tinnitus in 72%,
and headache in 92%
5 of 51 with
abdominal
discomfort
2b
Yamazaki et al
(1982)
23
Symptomatology, PTA,
ECoG
2 had hearing
improvement, 2 had
hearing loss
In 18 of 20 who
experienced relief,
attack of vertigo did
not occur in 12
(63%) and vertigo
relieved in 6 (31%)
None reported
4
Brookes and Booth
(1984)
12
Symptomatology, PTA 3 of 13 noted gains
but could be clearly
substantiated in only
1
Symptomatic
improvement in the
Me´nie`re’s symptoms
reported by only 4
of 13
Side effects in 6 of 13
(46.2%);
paraesthesias in 12
of 13; 4 with
headaches, 3 with
drowsiness, 1 with
chest tightness
4
van Deelen and
Huizing (1986)
11
Symptomatology, PTA No positive effect on
hearing
Significant decrease of
vertigo
None reported
1a
Corvera and Corvera
(1989)
24
PTA
In short term (2-6
wk), decrease of
average hearing loss
observed with both
chlorthalidone and
acetazolamide; in the
long term (
.
5 y), no
preventive effect on
deterioration of the
hearing loss
Not assessed
None reported
3b
Raivio et al (1989)
20
PTA, glycerol test, and
electronystagmography
with caloric testing
In 58 of 104 cases
(55.8%), the
‘‘treatment was
effective’’
In 46 of 104 (44.2%),
the vertigo was not
under control
2 with disabling
hypotension
4
Santos et al (1993)
21
1985 CHE reporting
guidelines, PTA
Hearing improved in
35%, unchanged in
29%, worse in 22%,
and could not be
classified by CHE
guidelines in 14%
Vertigo control
complete or
substantial in 79%,
limited or
insignificant in 19%,
and worse in 2%
None reported
4
Kanda et al (1993)
14
1985 CHE reporting
guidelines, PTA
Improvement in 7 of
32 (22%); hearing
deterioration (
.
10-
dB loss) in 13
patients (41%); good
control of tinnitus by
in 21%
Vestibular symptoms
in 80% of patients
improved
None reported
4
Kakigi et al (1995)
26
PTA
57 (39.3%) of 145 ears
showed hearing
None reported
None reported
4
(continued)
Otolaryngology–Head and Neck Surgery 154(5)
29