48 / 264
Table 2.
Medication Regimen and Follow-up of the Included Studies.
Study
Medication
Regimen
Follow-Up
Norell and Stahle (1962)
18
Hydrochlorothiazide
Day 1-4: 25 mg TID; days 5-21:
15-25 mg BID
6 mo
Varga et al (1966)
22
Acetazolamide
Day 1: 500 mg, with 250 mg
TID; day 2: 250 mg QID; days
3-13: 250 mg TID
10 d, 6 mo, 1 y, 5 y
Klockhoff and Lindblom (1967)
8
Hydrochlorothiazide
25 mg TID, 6 d/wk
2 y
Klockhoff et al (1974)
16
Chlorthalidone
Salt restriction, 50 or 100 mg
daily; in some exceptional
cases, doses of 150 or 200 mg
were administered for short
periods
5 y
Petermann et al (1982)
10
Betahistine dihydrochloride or
hydrochlorothiazide
Betahistine: 8 mg TID;
hydrochlorothiazide: 25 mg
TID
9 mo
Kitahara et al (1982)
9
Isosorbide
30 mL TID for 1 wk, then 20
mL TID for 2 wk, then 15-mL
dose TID for an indefinite
period
6 mo
Yamazaki et al (1982)
23
Isosorbide
70 mL TID for 1 wk
4 mo
Brookes and Booth (1984)
12
Acetazolamide
250 mg daily or 500 mg
sustained-release preparation
Up to 9 mo
van Deelen and Huizing (1986)
11
‘‘Dyazide’’ (50 mg, triamterene;
25 mg, hydrochlorothiazide)
First 3 d of each period: 2
capsules daily; during the
remaining period, 2 capsules
every second day
17 wk
Corvera and Corvera (1989)
24
Chlorthalidone or
acetazolamide
Chlorthalidone: 50-100 mg
every other day;
acetazolamide: 500-750 mg
daily, 5 d/wk
Chlorthalidone group, 5-13.4 y;
acetazolamide range, 5-7.8 y;
control group, 5-24.1 y
(continued)
Table 1.
(continued)
Study Title
Author (Year)
Country
Patients, n Study Type
Diagnostic Criteria
Me´nie`re’s Disease: Clinical
Experience’’
‘‘Effects of Long-term Treatment
with Osmotic Diuretics on
Symptoms and Electro-
cochleogram in Meniere’s
Disease’’
Kitahara et al (2004)
15
Japan
7 RCS
Japan Society for Equilibrium
Research for Me´nie`re’s disease
‘‘Hearing and Dizziness in
Patients with Definite
Meniere’s Disease after the
Long Term Use of Diuretics’’
Chung et al (2010)
13
South Korea
27 RCS
1995 AAO-HNS guidelines
‘‘Are Thiazides Effective on
Hypertensive Vertigo? A
Preliminary Study’’
Eryaman et al (2012)
25
Turkey
24 Case-control
Internal/independent criteria
Abbreviations: AAO-HNS, American Academy of Otolaryngology—Head and Neck Surgery; AAOO, American Academy of Ophthalmology and
Otolaryngology; RCS, retrospective case series; RCT, randomized controlled trial.
Otolaryngology–Head and Neck Surgery 154(5)
27