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Tissue architecture (2)
FSUs in an organ can be organized in ’series’ or in
’parallel’
The dose-volume behaviour can be thought of as a
mixture of two ’extreme’ situations of cell organization
patterns
From a mechanistic point of view the probability of a
complication depends on the cell killing in FSU, on the
organization of the FSUs and on how they carry out the
function of the organ
Withers et al, IJROBP, 1988