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The dose-volume is generally a mixture
of
two
extreme situations of cell organization patterns:
parallel organs
,
whose functionality is highly impaired,
causing a complication, when irradiating
a significant percentage of the total
volume
late reactions, e.g. lung, liver, kidney, parotids
serial organs
,
where reaching a well defined dose
level severely impairs the organ
functionality, meaning that there is only a
small volume effect
acute reactions e.g. mucositis
late reactions, e.g. nervous system, paralysis
More correct to characterize organs in terms of their organ reserve