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Mechanistic modelling

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Empirical

models are statistical tools enabling the

treatment planner to use clinical experience efficiently.

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Assume a black box between input (dose distribution) and

output (outcome)

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Based on DVHs; ignore internal organ substructures and

variation in response across the organ.

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Attempts have been made to develop more

mechanistic

models of normal tissue response.

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The outcome is modelled as a consequence of

mechanisms in the normal tissue triggered by radiation.

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Parameter values from experiments, assays of tissue

function and simulations