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Background
Definition:
•
The major polysaccharide in aloe is glucomannan
which is consisted of mannose (major) and glucose
(minor) with 1,4‐β‐linked backbone;
•
The mannose moieties are highly acetylated and are
referred to acetylated glucomannan polysaccharides;
Glc
p
x
O
HO
HO
O
HOH
2
C
O
HO
OH
O
HOH
2
C
O
HO
HO
O
HOH
2
C
O
Man
p
Man
p
y
z
2/3/6-OAc
2/3/6-OAc
1
2
3
4 5
6
Structure of the major
aloe polysaccharides
Background
Summary of current methods used in Aloe
qualification (identification) and quantitation analysis:
•
1
H NMR
–
Qualification of aloe raw material and product;
–
Quantitation of polysaccharides by analysis of the content
of acetyl groups;
–
Quantitation of organic acids including acetic acid, lactic
acid, malic acid and isocitric acid;