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1702-Plat
8:45 am
CRYOEM-GUIDED ITERATIVE MOLECULAR DYNAMICS - ROSETTA PROTEIN
STRUCTURE REFINEMENT PROTOCOL IMPROVES PROTEIN MODEL QUAL-
ITY.
Steffen Lindert
, Melanie Marlett
1703-Plat
9:00 am
STRUCTURE-BASED PREDICTION OF PROTEASE MULTISPECIFICITY USING
COMPUTATIONAL PROTEIN DESIGN.
Sagar D. Khare
, Aliza Rubenstein,
Manasi Pethe
1704-Plat
9:15 am
PROTEIN SEQUENCE OPTIMIZATION WITH A POLARIZABLE FORCE FIELD:
INSIGHTS FROM PDZ DOMAINS. Jacob M. Litman, Young Joo Sun, Titus
Hou, Stephen D. LuCore, Nicolas Panel, Thomas Simonson, Ernesto J.
Fuentes,
Michael J. Schnieders
1705-Plat
9:30 am
DE NOVO DESIGN AND BIOPHYSICAL CHARACTERIZATION OF AN AFFIN-
ITY-ENHANCED PROTEIN DISPLAYING THE STRUCTURE OF THE BROADLY
NEUTRALIZING HIV-1 2F5 ANTIBODY EPITOPE.
Isabelle Freire Tabosa
Viana
, Eduardo Nascimento, Jodi Craigo, Marco Krieger, Robbie Mailliard,
Rafael Dhalia, Roberto Lins, Ernesto TA Marques
1706-Plat
9:45 am
A TOOL TO INTEGRATE USER EXPERTISE INTO BUILDING ATOMIC LEVEL
MODELS FOR LARGE BIOMOLECULAR SYSTEMS.
Till Rudack
, Ryan
McGreevy, Marc Siggel, Klaus Schulten
1707-Plat
10:00 am
RESIDUE ENVIRONMENT SCORE FOR SELECTING PROTEIN STRUCTURE
MODELS AND PROTEIN-PROTEIN DOCKING MODELS.
HyungRae Kim
Platform
Protein Assemblies
8:15 am - 10:15 am, Room 515A
Co-Chairs
James Cole, University of Connecticut
Alasdair Steven, NIH
1708-Plat
8:15 am
SPECIFIC INTERACTION OF A NATURALLY OCCURRING AMYLOIDOGENIC
FRAGMENT OF STREPTOCOCCUS MUTANS ADHESIN P1 WITH INTACT P1
ON THE CELL SURFACE MEASURED BY SOLID STATE NUCLEAR MAGNETIC
RESONANCE SPECTROSCOPY.
Joanna Long
, Wenxing Tang, Paula Crowley,
L. Jeannine Brady
1709-Plat
8:30 am
REGULATION OF PKR BY RNA: FORMATION OF ACTIVE AND INACTIVE
DIMERS. Bushra Husain, Stephen Hesler,
James Cole
1710-Plat
8:45 am
EDUCATION TRAVEL AWARDEE
GOVERNING PRINCIPLES OF MULTIPROTEIN COMPLEX FORMATION ON
THE CELL MEMBRANES: AN INVESTIGATION USING SINGLE-MOLECULE
RESOLUTION SPATIO-TEMPORAL STOCHASTIC COMPUTER SIMULATIONS
AND ANALYTICAL CALCULATIONS.
Osman N. Yogurtcu
, Margaret E.
Johnson
1711-Plat
9:00 am
CHARACTERIZATION OF NOVEL SPLIT-FLUORESCENT PROTEINS AND
QUANTITATIVE ANALYSIS OF THEIR SELF-ASSEMBLY PROCESS.
Tugba
Koker
, Anthony Fernandez, Arunima Kolekar, Fabien Pinaud
1712-Plat
9:15 am
A NEW DIMENSION OF DETECTION IN ANALYTICAL ULTRACENTRIFUGA-
TION WITH FLUORESCENCE DETECTION USING PHOTOSWITCHABLE
FPS AS TIME DOMAIN PROBES.
Huaying Zhao
, George Patterson, Peter
Schuck
1713-Plat
9:30 am
MOLECULAR ARCHITECTURE OF THE NUP82 COMPLEX, THE CYTOPLAS-
MIC MRNA EXPORT PLATFORM IN THE NUCLEAR PORE COMPLEX.
Seung
Joong Kim
, Javier Fernandez-Martinez, Yi Shi, Paula Upla, Riccardo
Pellarin, Ilan E. Chemmama, Ilona Nudelman, David L. Stokes, Brian T.
Chait, Andrej Sali, Michael P. Rout
1714-Plat
9:45 am
LOCAL GEOMETRY AND EVOLUTIONARY CONSERVATION OF PROTEIN
SURFACES REVEAL THE MULTIPLE RECOGNITION PATCHES IN PROTEIN-
PROTEIN INTERACTIONS.
Elodie Laine
, Hugues Ripoche, Alessandra
Carbone
1715-Plat
10:00 am
RETINOSCHISIN AT 4 Å RESOLUTION FROM CRYO-EM: A JUNCTIONAL
MODEL OF BACK-TO-BACK OCTAMERS FOR ADHESION IN THE RETINA.
Gökhan Tolun, Camasamudram Vijayasarathy, Rick Huang, Yong Zeng, Yan
Li, Paul A. Sieving, J. Bernard Heymann,
Alasdair C. Steven
Platform
Mechanosensation
8:15 am - 10:15 am, Room 515B
Co-Chairs
Dolores Bozovic, University of California, Los Angeles
Hongxia Fu, Harvard Medical School
1716-Plat
8:15 am
SINGLE-MOLECULE ACTIVATION BY FLOW: FORCE-INDUCED CONFORMA-
TIONAL TRANSITIONS REGULATE THE LIGAND BINDING AFFINITY OF A
LARGE, POLYMERIC MECHANOSENSOR PROTEIN.
Hongxia Fu
, Yan Jiang,
Darren Yang, Wesley P. Wong, Timothy A. Springer
1717-Plat
8:30 am
BILAYER-MEDIATED STRUCTURAL TRANSITIONS IN THE TREK-2 MECHA-
NOSENSITIVE K2P CHANNEL.
Prafulla Aryal
, Viwan Jarerattanachat,
Stephen J. Tucker, Mark S.P. Sansom
1718-Plat
8:45 am
MAGNETIC NANOPARTICLE STIMULATION FOR DETECTION OF HIGH-OR-
DER MODE-LOCKING IN HAIR CELLS OF THE INNER EAR.
Dolores Bozovic
,
Michael Levy
1719-Plat
9:00 am
STRETCH-GATED ION CHANNELS IN NEURONAL MECHANORECEPTORS.
Slav N. Bagriantsev
, Eve R. Schneider, Evan O. Anderson, Jon Matson,
Elena O. Gracheva
1720-Plat
9:15 am
BIOPHYSICAL FACTORS THAT PROMOTE MECHANICALLY-INDUCED AC-
TION POTENTIALS IN NEOCORTICAL AND HIPPOCAMPAL PYRAMIDAL
NEURONS. Yury A. Nikolaev, Peter J. Dosen, Derek R. Laver, Dirk F. Van
Helden,
Owen P. Hamill
1721-Plat
9:30 am
CPOW TRAVEL AWARDEE
INFLAMMATORY CYTOKINE IL-1α UP-REGULATES PIEZO1 AND HYPER-
SENSITIZES CHONDROCYTES TO COMPRESSION.
Whasil Lee
, Holly Leddy,
Amy McNulty, Farshid Guilak, Wolfgang Liedtke
1722-Plat
9:45 am
STRUCTURAL AND FUNCTIONAL CHARACTERIZATIONS OF THE MECHA-
NOSENSITIVE PIEZO CHANNEL.
Bailong Xiao
1723-Plat
10:00 am
BENDING PIEZO1: THE EFFECT OF AMPHIPATHS ON THE GATING OF A
MECHANOSENSITIVE CHANNEL.
Charles D. Cox
, Boris Martinac