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Platform
Cell Mechanics, Mechanosensing, and Motility I
10:45 am - 12:45 pm, Room 502B
Co-Chairs
Melissa Knothe Tate, University of New South Wales, Australia
Mohammad Mofrad, University of California, Berkeley
129-Plat
10:45 am
MECHANO-SENSITIVE INTERACTION BETWEEN TALIN AND FULL-LENGTH
VINCULIN.
Yinan Wang
, Benjamin T. Goult, Mingxi Yao, Jie Yan
130-Plat
11:00 am
DISSIPATION OF STRESS IN THE CYTOSKELETON VIA ALPHA-ACTININ
DYNAMIC CROSSLINKING.
Hossein Khadivi Heris
, Adele Khavari, Adam
Hendricks, Allen Ehrlicher
131-Plat
11:15 am
MECHANOTRANSDUCTION OF THE ENDOTHELIAL GLYCOCALYX MEDIATES
NITRIC OXIDE PRODUCTION THROUGH ACTIVATION OF TRP CHANNELS.
Matthew Dragovich
, Daniel Chester, X. Frank Zhang
132-Plat
11:30 am
A LAMIN A CHIMERIC PROTEIN CONTAINING A FRET BASED STRESS SEN-
SORS REPORTS SPATIO-TEMPORAL FORCES IN THE NUCLEAR LAMINA.
Thomas M. Suchyna
, Fanji Meng, Frederick Sachs, Wilma Hofmann
133-Plat
11:45 am
EDUCATION TRAVEL AWARDEE
MOLECULAR MECHANISMS OF MECHANOTRANSDUCTION THROUGH
LINC COMPLEXES.
Zeinab Jahed
, Hengameh Shams, Mohammad Mofrad
134-Plat
12:00 pm
CELL INVASION THROUGH STIFF CONSTRICTIONS CAUSES MUTATIONS
WHILE DAMAGING THE NUCLEUS.
Jerome Irianto
, Charlotte R. Pfeifer,
Avathamsa Athirasala, Irena L. Ivanovska, Roger E. Greenberg, Dennis E.
Discher
135-Plat
12:15 pm
VISUALIZING DIRECT INTERACTIONS IN THE MECHANOBIOME.
Priyanka
Kothari
, Vasudha Srivastava, Irina Tchernyshyov, Jennifer Van Eyk, Douglas
N. Robinson
136-Plat
12:30 pm
MAPPING THE MECHANOME: NEW EXPERIMENTAL AND COMPUTA-
TIONAL APPROACHES TO ELUCIDATE STEM CELL MECHANOADAPTATION
AND LINEAGE COMMITMENT.
Melissa L. Knothe Tate
, Iman Jalilian, Min
Jae Song, Sara McBride
Platform
TRP Channels
10:45 am - 12:45 pm, Room 515A
Co-Chairs
Avi Priel, The Hebrew University of Jerusalem, Israel
Theodore Wensel, Baylor College of Medicine
137-Plat
10:45 am
THE STOICHIOMETRY AND ACTIVATION MECHANISM OF TRPV1 BY VANIL-
LOIDS. Rakesh Kumar, Adina Hazan, Henry Matzner,
Avi Priel
138-Plat
11:00 am
ION-ION INTERACTION AT THE MULTI-ION TRPV1 PORE.
Bo Hyun Lee
, Jie
Zheng
139-Plat
11:15 am
A COMBINED COARSE-GRAINED AND ALL-ATOMMOLECULAR SIMULA-
TION OF THE TRPV1 CHANNEL.
Wenjun Zheng
140-Plat
11:30 am
N-HMME UPREGULATES LIPOLYTIC PROTEINS IN THE LIVER TO COUNTER
NAFLD.
Padmamalini Baskaran
, Ross Cook, Sara Cisneros, Steven
McAllisted, Baskaran Thyagarajan
141-Plat
11:45 am
STRUCTURE OF THE FULL-LENGTH TRPV2 CHANNEL BY CRYOEM.
Kevin
Huynh
142-Plat
12:00 pm
STRUCTURAL BASIS OF TRPV2 CHANNEL GATING INVESTIGATED WITH
CRYO-EM.
Timothy L. Dosey
, Zhao Wang, Fan Guizhen, Irina I. Serysheva,
Wah Chiu, Theodore G. Wensel
143-Plat
12:15 pm
STRUCTURE OF THE TRPA1 ION CHANNEL SUGGESTS REGULATORY
MECHANISMS.
Candice E. Paulsen
, Jean-Paul Armache, Yuan Gao, Yifan
Cheng, David Julius
144-Plat
12:30 pm
THE ROLE OF LIPID RAFTS IN THE LOCALIZATION AND FUNCTION OF THE
CHEMOSENSORY TRPA1 CHANNEL.
Justyna B. Startek
, Debapriya Ghosh,
Yeranddy A. Alpizar, Alejandro López-Requena, Nele Van Ranst, Thomas
Voets, Karel Talavera
Platform
Protein Assembly and Function
10:45 am - 12:45 pm, Room 515B
Co-Chairs
Jennifer Boatz, University of Pittsburgh
Jochen Mueller, Ludwig Maximilian University of Munich, Germany
145-Plat
10:45 am
STRUCTURAL STUDIES OF THE OLIGOMERIZATION PROCESS OF HUMAN
CYSTATIN C VARIANTS. Zuzanna Pietralik, Magdalena Murawska, Aneta
Szymanska, Janet R. Kumita, Christopher M. Dobson,
Maciej Kozak
146-Plat
11:00 am
THE STRUCTURAL BASIS OF ENZYME REGULATION BY CTP SYNTHASE
METABOLIC FILAMENTS. Eric Lynch,
Justin Kollman
147-Plat
11:15 am
TUBULIN MONOMER-MONOMER ASSOCIATION IS LESS INFLUENCED
BY THE SOLVENT THAN DIMER-DIMER ASSOCIATION: STRUCTURE AND
FUNCTION OF TUBULIN INTERACTION INTERFACES.
Felipe Montecinos-
Franjola
, Peter Schuck, Dan L. Sackett
148-Plat
11:30 am
STRUCTURAL STUDIES OF PLANT CESA SUPPORT EIGHTEEN CESAS IN THE
PLANT CSC.
Venu G. Vandavasi
, Daniel K. Putnam, Qiu Zhang, Loukas Pe-
tridis, William T. Heller, B. Tracy Nixon, Candace H. Haigler, Udaya Kalluri,
Leighton Coates, Paul Langan, Jeremy C. Smith, Jens Meiler, Hugh O’Neill
149-Plat
11:45 am
STRUCTURAL INSIGHTS INTO TC TOXIN ACTION.
Stefan Raunser
150-Plat
12:00 pm
AN INVESTIGATION OF THE ATOMIC STRUCTURE OF CATARACT-FORM-
ING MUTANT GAMMA-D-CRYSTALLIN AGGREGATES FORMED UNDER
DISTINCT ENVIRONMENTAL CONDITIONS.
Jennifer C. Boatz
, Matthew J.
Whitley, Cody L. Hoop, Xuemei Zeng, Nathan Yates, Angela M.
Gronenborn, Patrick C A van der Wel
151-Plat
12:15 pm
THE GIANT CYTOSKELETAL PROTEIN OBSCURIN ACTS AS A VARIABLE
FORCE RESISTOR.
Nathan T. Wright
, Tracy A. Caldwell, Logan C. Meyer