Biophysical Society 60th Annual Meeting

152-Plat

12:30 pm

FORCE SENSING BY THE VASCULAR PROTEIN VON WILLEBRAND FAC-

TOR IS TUNED BY A STRONG INTERMONOMER INTERACTION.

Jochen P.

Mueller

, Salomé Mielke, Achim Löf, Tobias Obser, Christof Beer, Diana A.

Pippig, Willem Vanderlinden, Reinhard Schneppenheim, Martin Benoit

Platform

Membrane Active Peptides and Toxins

10:45 am - 12:45 pm, Room 501ABC

Co-Chairs

Estefania Mulvihill, Eidgenössische Technische Hochschule Zürich,

Switzerland

Marc-Antoine Sani, University of Melbourne, Australia

153-Plat

10:45 am

A PORE MODEL OR THE CARPET MODEL? THE MODE OF ACTION OF

AMPS ON E. COLI SPHEROPLASTS. Yen Sun, Tzu-Lin Sun,

Huey W. Huang

154-Plat

11:00 am

PROBING THE ANTIMICROBIAL ACTION OF POLYMYXIN B1 AND MELITTIN

VIA COARSE-GRAINED MOLECULAR DYNAMICS SIMULATIONS.

Damien F.

Jefferies

, Pin-Chia Hsu, Syma Khalid

155-Plat

11:15 am

THE DISRUPTIVE STATE OF THE MEMBRANE ACTIVE ANTIMICROBIAL

PEPTIDE PISCIDIN 1 INVESTIGATED BY MULTI-μS ALL-ATOM SIMULATIONS

AND SOLID-STATE NMR: SURFACE DEFECTS ARE FAVORED OVER STABLE

PORES.

B. Scott Perrin Jr

, Riqiang Fu, Myriam Cotten, Richard W. Pastor

156-Plat

11:30 am

DIRECTLY OBSERVING THE LIPID-DEPENDENT SELF-ASSEMBLY AND PORE

FORMING MECHANISM OF THE CYTOLYTIC TOXIN LISTERIOLISYN O.

Estefania S. Mulvihill

, Katharina van Pee, Stefania Mari, Daniel J. Mueller,

Özkan Yildiz

157-Plat

11:45 am

LIPID-PROTEIN PARTNERING DURING PORE FORMATION OF FRAGACEA-

TOXIN C.

Koldo Morante

, Jose M. M. Caaveiro, Kouhei Tsumoto

158-Plat

12:00 pm

INHIBITION OF RTX TOXIN ACTIVITY BY THE NUCLEAR STAIN, DRAQ5.

Angela C. Brown

, Joshua Webb

159-Plat

12:15 pm

MEMBRANE-BINDING PROPERTIES OF GATING-MODIFIER AND PORE

BLOCKING TOXINS: MEMBRANE INTERACTION IS NOT A PREREQUISITE

FOR MODIFICATION OF CHANNEL GATING.

Evelyne Deplazes

, Sónia

Troeira Henriques, Glenn F. King, David J. Craik, Alan E. Mark, Christina I.

Schroeder

160-Plat

12:30 pm

STRUCTURAL CHANGES IN LIPID MODEL MEMBRANES INDUCED BY THE

FUNGAL PEPTIDE TOXIN ECE1-III.

Julia Wernecke

, Laura Paulowski,

Bernhard Hube, Oliver H. Seeck, Thomas Gutsmann

Platform

Cardiac Smooth and Skeletal Muscle

Electrophysiology

10:45 am - 12:45 pm, Room 511ABC

Co-Chairs

Edward Lakatta, NIH

Eric Sobie, University of Maryland Biotechnology Institute

161-Plat

10:45 am

SUBSTANTIAL CELL-TO-CELL HETEROGENEITY OF ION CURRENTS IS AN ES-

SENTIAL CHARACTERISTIC OF THE SINOATRIAL NODE.

Oliver J. Monfredi

Bruce Ziman, Mark Boyett, Edward Lakatta, Victor A. Maltsev

162-Plat

11:00 am

INTERNATIONAL TRAVEL AWARDEE

SK4 K

CHANNELS REGULATE SINOATRIAL PACEMAKER AND THEIR BLOCK-

ADE AMELIORATE ARRHYTHMIAS IN CPVT2 PATIENT-DERIVED IPSC AND

IN VIVO IN CASQ2 KNOCK-IN AND KNOCK-OUT MICE.

Shiraz

Haron-Khun

, David Weisbrod, Dor Yadin, Asher Peretz, Michael Eldar,

Michael Arad, Bernard Attali

163-Plat

11:15 am

ACTION POTENTIAL MORPHOLOGY MEASUREMENT OF CARDIAC CELL

CHAMBER SPECIFIC CELL TYPES OF STEM CELL-DERIVED CARDIAC MYO-

CYTES. Aaron D. Kaplan, Glenna CL Bett,

Randall L. Rasmusson

164-Plat

11:30 am

FLUORESCENCE LOCAL FIELD OPTICAL MAPPING (FLOM) OF CA

AL-

TERNANSES TEMPERATURE DEPENDENCY IN INTACT PERFUSED MOUSE

HEARTS.

Yuriana Aguilar-Sanchez

, Moris A. Saravia, Jose Millet, Ariel L.

Escobar

165-Plat

11:45 am

SUDDEN INFANT DEATH AND MODULATION OF LATE SODIUM CURRENT

BY HYPOXIA, INVESTIGATED IN INDUCED PLURIPOTENT STEM CELLS.

Stefan A. Mann

, Jamie I. Vandenberg, Adam P. Hill

166-Plat

12:00 pm

INCREASED SUSCEPTIBILITY OF SPONTANEOUSLY HYPERTENSIVE RATS

TO VENTRICULAR TACHYARRHYTHMIAS DURING THE EARLY STAGES OF

HYPERTENSION.

Christopher Y. Ko

, Thao P. Nguyen, Ali A. Sovari, Arash

Pezhouman, Shankar Iyer, Hong Cao, Aneesh Bapat, Nooshin Vahdani,

Mostafa Ghanim, Michael C. Fishbein, James N. Weiss, Hrayr S.

Karagueuzian

167-Plat

12:15 pm

EXTRACELLULAR SODIUM DEPENDENCE OF THE CONDUCTION VELOCITY-

CALCIUM RELATIONSHIP: EVIDENCE OF EPHAPTIC SELF-ATTENUATION.

Sharon George

, Mohammad Bonakdar, Michael Zeitz, Rafael Davalos,

James Smyth, Steven Poelzing

168-Plat

12:30 pm

EVIDENCE FOR PHOSPHORYLATION-DEPENDENT MODULATION OF BK

CHANNEL ACTIVITY IN VASCULAR SMOOTH MUSCLE (VSM) MYOCYTES

AND RESISTANCE ARTERIES. Barry D. Kyle, Ramesh C. Mishra,

Andrew P.

Braun

Undergraduate Student Pizza “Breakfast”

11:30 am - 1:00 pm, Room 406AB

The Education Committee hosts this “breakfast” for undergraduate stu-

dents. This session provides a valuable networking and social opportunity

to meet other students and Committee members, to discuss academic

goals and questions, and to develop a biophysics career path. Space is

limited to the first 100 registrants. Meeting attendees do not need to pre-

Colleges in the Community Day

11:30 am - 5:00 pm, Room 406AB

This full day of activities for local college students and their instructors

kicks off with an Undergraduate Student Pizza “Breakfast” where par-

ticipants have an opportunity to socialize and network with their peers

and members of the Biophysical Society’s Education Committee in a fun

and relaxed environment. Next, students have a chance to win prizes

during a scavenger hunt designed to promote learning and interaction

with researchers. Undergraduates also have a unique opportunity to ask

graduate students, postdocs, and leading biophysicists about training

and career opportunities in biophysics and related fields during this

interactive Q & A session. Come prepared to find out about the course

of study that biophysicists undertake, what it means to be a biophysicist,

and how biophysicists make important discoveries. Finally, students have

access to an exclusive tour of the Exhibit Hall where they will view special

demonstrations featuring cutting edge instrumentation producing break-

throughs in structural biology and other areas.