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195-Plat
5:30 pm
STIRRING A LOW REYNOLDS NUMBER MARTINI.
Edward R. Lyman
196-Plat
5:45 pm
VENI, VIDI, VORONOI: ATTACKING VIRUSES WITH SPHERICAL VORONOI
DIAGRAMS.
Tyler Reddy
, Ross Hemsley, Edd Edmondson, Nikolai Nowac-
zyk, Joe Pitt-Francis, Mark S.P. Sansom
Platform
Intrinsically Disordered Proteins (IDP)
and Aggregates I
4:00 pm - 6:00 pm, Room 515B
Co-Chairs
Claudiu Gradinaru, University of Toronto, Canada
Ana Melo, University of Pennsylvania
197-Plat
4:00 pm
CPOW TRAVEL AWARDEE
DETERMINING A TOPOLOGICAL MODEL FOR TAU BOUND TO TUBULIN
HETERODIMERS.
Ana M. Melo
, Garrett Cobb, Juliana Coraor, Shana
Elbaum-Garfinkle, Elizabeth Rhoades
198-Plat
4:15 pm
A NEW APPROACH TO INFER SIZE AND SHAPE OF DISORDERED CONFOR-
MATIONS OF PROTEINS FROM SM-FRET DATA. Gregory-Neal Gomes,
Jianhui Song, Hue-Sun Chan,
Claudiu C. Gradinaru
199-Plat
4:30 pm
FTIR STUDY REVEAL INTRINSICALLY DISORDERED NATURE OF HEAT
SHOCK PROTEIN 90.
Aihua Xie
, Maurie Balch, David Neto, Oliver Causey,
Johnny Hendriks, Junpeng Deng, Robert Matts
200-Plat
4:45 pm
PHYSICAL PRINCIPLES THAT GOVERN THE SEQUENCE-ENCODED PHASE
BEHAVIOR OF INTRINSICALLY DISORDERED BLOCK-COPOLYMERIC
PROTEINS.
Alex S. Holehouse
, Tyler S. Harmon, Rohit V. Pappu
201-Plat
5:00 pm
CYTOTOXICITY OF PRION PROTEIN-DERIVED CELL PENETRATING PEPTIDES
IS INDEPENDENT OF AMYLOID FORMATION. Vineeth Mukundan, Christy
Maksoudian, Maria Vogel,
Mazin Magzoub
202-Plat
5:15 pm
INTRINSICALLY DISORDERED PROTEINS DRIVE MEMBRANE CURVATURE.
David J. Busch
, Justin R. Houser, Carl C. Hayden, Michael B. Sherman,
Eileen M. Lafer, Jeanne C. Stachowiak
203-Plat
5:30 pm
KINETICS OF AMYLOID FIBRIL SELF-ASSEMBLY BY DIRECT OBSERVATION
OF ELONGATION.
Laurence J. Young
, Clemens F. Kaminski
204-Plat
5:45 pm
FROM PHYSIOLOGICAL FLUIDS TO PATHOLOGICAL GELS: DISORDERED
PROTEINS AT THE NEXUS OF LIQUID PHASE SEPARATION AND NEURODE-
GENERATIVE DISEASE. Shana Elbaum-Garfinkle,
Nicole Taylor
, Clifford P.
Brangwynne
Platform
Membrane Protein Structure and Folding I
4:00 pm - 6:00 pm, Room 501ABC
Co-Chairs
Vadim Cherezov, University of Southern California
Syma Khalid, University of Southampton, United Kingdom
205-Plat
4:00 pm
ARNT: STRUCTURE AND MECHANISM OF THE AMINOARABINOSE
TRANSFERASE RESPONSIBLE FOR RESISTANCE TO POLYMYXIN-CLASS
ANTIBIOTICS.
Vasileios I. Petrou
, Carmen M. Herrera, Kathryn M. Schultz,
Oliver B. Clarke, Jeremie Vendome, David Tomasek, Surajit Banerjee,
Kanagalaghatta R. Rajashankar, Brian Kloss, Edda Kloppmann, Burkhard
Rost, Candice S. Klug, M. Stephen Trent, Lawrence Shapiro, Filippo
Mancia
206-Plat
4:15 pm
STRUCTURAL STUDIES OF THE HUMAN KAPPA OPIOID RECEPTOR
ACTIVE STATE CONFORMATIONS.
Ming-Yue Lee
, Nilkanth Patel, Vsevolod
Katritch, Raymond C. Stevens, Vadim Cherezov
207-Plat
4:30 pm
CRYSTAL STRUCTURE OF THE CALCIUM ATPASE SERCA IN COMPLEX TO A
NOVEL ANTI-CANCER AGENT THAT TARGETS MULTIDRUG-RESISTANT
LEUKEMIA.
John K. Lee
, Joseph M. Autry, Razvan Cornea, Nicholas
Bleeker, Denise Casemore, Chengguo Xing, David D. Thomas
208-Plat
4:45 pm
CPOW TRAVEL AWARDEE
ADVANCES IN IN SITU X-RAY CRYSTALLOGRAPHY OF MEMBRANE
PROTEINS.
Jana Broecker
, Viviane Klingel, Bryan T. Eger, Oliver P. Ernst
209-Plat
5:00 pm
A MACHINE LEARNING APPROACH TO HETEROLOGOUS MEMBRANE
PROTEIN OVEREXPRESSION.
ShyamM. Saladi
, Nauman Javed, Axel
Müller, WilliamM. Clemons
210-Plat
5:15 pm
LINKING THE OUTER MEMBRANE OF E.COLI TO THE CELL WALL VIA
OMPA & BRAUN’S LIPOPROTEIN: TOWARDS A MOLECULAR MODEL OF A
VIRTUAL BACTERIAL CELL ENVELOPE.
Syma Khalid
, Maite Ortiz-Suarez,
Peter J. Bond, Thomas Piggot
211-Plat
5:30 pm
SYSTEMATIC EVALUATION OF THE CS-ROSETTA DE NOVO STRUCTURE
PREDICTION METHOD FOR MEMBRANE PROTEINS.
Katrin Reichel
,
Olivier Fisette, Tatjana Braun, Gerhard Hummer, Oliver Lange, Lars
Schäfer
212-Plat
5:45 pm
INSIGHTS INTO HOWMUTATIONS THERMOSTABILIZE G-PROTEIN-COU-
PLED RECEPTORS.
Nagarajan Vaidehi
, Sangbae Lee, Supriyo
Bhattacharya, Manbir Sandhu, Reinhard Grisshammer, Christopher G.
Tate