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( )

(

)

( )

[

]

[

]

1

1

=

− Θ =

i

N

j

p

i

j

i

L

i

j

i

L

i

i

d D d D

N

f

x

x

Low-Objective for PTV

D

L

= D

V

for V

100%

L

H

( )

(

)

( )

[

]

[

]

1

1

=

− Θ =

i

N

j

p i

H

i

j

i

H

i

j

i

i

D d D d

N

f

x

x

High-Objective for PTV

D

H

= D

V

for V

0%

L

H

General Form of an

Objective Function

and DVH

Inverse Optimisation and Planning

(2000 – today)