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FOR EXPERT REVIEW PANEL USE ONLY
NOT FOR DISTRIBUTION
3
•
A quadratic curve has been used for calibration. Only 4 points are employed for making the quadratic
curve (may be the limit for a quadratic) – plot of relative error indicates in most cases the error is less
than 5% (one exception at lowest level).
•
Performance Characteristics:
Analytical Range: tested
0.05 – 3.0 (SMPR goes up to 5.0)
LOQ: assessed to be 0.03 g/100g in water solution containing sucrose. Might also be interesting to
assess in blank matrix.
Accuracy/Recovery:
92.9 – 108%
(meets SMPR 90 – 110).
Precision (RSD
r
):
1.09 – 3.67
(meets SMPR <= 6)
(RSD iR): 2.46 – 6.79 (no specification in SMPR)
Reproducibility (RSD
R
): n/a
•
System suitability:
-
Blank samples have been analysed and found to be blank.
-
Otherwise no mention of the use of check standards or blank check samples
Recommendation:
- Write method in appropriate format
- Better describe the actual spiking levels in spike/recovery experiments
- Good candidate for 1
st
action
FOS-04 Review Forms