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Life Span Study
adverse effects of radiation in atomic bomb survivors (Hiroshima, Nagasaki)
~ 90.000 survivors
irradiated with mainly photons and small portion of neutrons
Mean whole body dose = 0.2 Sv
97.6% had whole body dose < 1 Sv
~ 36.000 persons had dose < 0.005 Sv (internal reference, negligible dose)
Between 0.05 Sv and 2 Sv
(single dose):
linear
dose response relationship for
induction of solid tumors
*BEIR VII, phase II, DDREF=1.5
100 mSv whole body to US population:
•
EAR
≈ 1%
1% of population will get radiation-induced tumor
•
ERR
≈ 2.5%
total number of tumors increases by 2.5%
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Clinical data
Clinical data