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Life Span Study

adverse effects of radiation in atomic bomb survivors (Hiroshima, Nagasaki)

~ 90.000 survivors

irradiated with mainly photons and small portion of neutrons

Mean whole body dose = 0.2 Sv

97.6% had whole body dose < 1 Sv

~ 36.000 persons had dose < 0.005 Sv (internal reference, negligible dose)

Between 0.05 Sv and 2 Sv

(single dose):

linear

dose response relationship for

induction of solid tumors

*BEIR VII, phase II, DDREF=1.5

100 mSv whole body to US population:

EAR

≈ 1%

1% of population will get radiation-induced tumor

ERR

≈ 2.5%

total number of tumors increases by 2.5%

17

Clinical data

Clinical data