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Second tumor:

Soft tissue sarcoma

15y incidence

of soft tissue sarcoma after RT

<0.5%

,

but

ERR=600%

relative to

general population

Rubino et al, 2005

: all soft tissue and bone sarcomas in irradiated women, were

located in irradiated fields or upper ipsilateral arm (

high dose areas

)

22

Clinical data: breast cancer

2

nd

tumors in patients treated for BREAST CANCER