1509 / 1542
Lancet 2005; 366: 2087–2106
•
meta analysis of 78 randomized trials
•
32.800 patients in studies evaluating addition of RT (50% irradiated)
ERR
2p
contralateral breast cancer
18% 0,002
lung cancer
61% 0,0007
oesophagus cancer
106% 0,05
leukemia
71% 0,04
soft-tissue carcinoma
134% 0,03
INCIDENCE
Exces cancer risk due to
radiotherapy
Close to irradiated tumor
19
Clinical data: breast cancer
2
nd
tumors in patients treated for BREAST CANCER