1510 / 1542
Second tumor:
contralateral breast cancer (CBC)
40-50%
of all secondary tumors are in the contralateral breast.
At 15y, 10-13%
of patients have developed contralateral tumor (2- to 5-fold
higher than general female population).
High risk for CBC is mostly unrelated to RT (
pre-disposition
).
Conflicting data
on contribution of RT: Some large studies show increased risk
for CBC due to RT, others only for young patients, others don’t show any
enhanced risk
Hormonal treatment with
tamoxifen reduces risk
for CBC by 30-40%
20
Clinical data: breast cancer
2
nd
tumors in patients treated for BREAST CANCER