Microsoft PowerPoint - L00 Introduction

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PLATO - PersonaLising Anal cancer

RadioTherapy dOse

53.2Gy 28F

58.8Gy

28F

61.6Gy

28F

T3/4 Nany,T2N2-3

ACT5

ACT3

T1 N0 Anal margin

Local excision

ACT4

T1,T2<4cm N0

Ph II

Ph III

Pilot

Pilot/Ph II/PhIII

N=677

Primary end point :- 3yr locoregional failure

Obs

n

Margin ≤1mm

41.4Gy 23F

Phase II trial

N=90

50.4Gy

28F

41.4Gy

23F

Randomised 2:1

Phase II trial

N=162