1048 / 1068
LY2606368
•
CHK1 is a multifunctional kinase crucial for checkpoint
control, DNA repair, cell cycle replication, and
proliferation.
•
Tumor cells with increased levels of CHK1 acquire
survival advantages due to the ability to tolerate a higher
level of DNA damage.
•
By inhibiting CHK1, tumour DNA is damaged and unable
to pass through mitosis.
•
The CHK 1/2 inhibitor (LY2606368) is being investigated
as a single agent in patients with metastatic SCCA and
plans to integrate with CRT
Although neutropenia is side effect